Defining and predicting ‘intrauterine fetal renal failure’ in congenital lower urinary tract obstruction

Rodrigo Ruano, Adnan Safdar, Jason Au, Chester J. Koh, Patricio Gargollo, Alireza A. Shamshirsaz, Jimmy Espinoza, Darrell L. Cass, Oluyinka O. Olutoye, Olutoyin A. Olutoye, Stephen Welty, David R. Roth, Michael A. Belfort, Michael C. Braun

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


Background: The aim of this study was to identify predictors of ‘intrauterine fetal renal failure’ in fetuses with severe congenital lower urinary tract obstruction (LUTO). Methods: We undertook a retrospective study of 31 consecutive fetuses with a diagnosis of LUTO in a tertiary Fetal Center between April 2013 and April 2015. Predictors of ‘intrauterine fetal renal failure’ were evaluated in those infants with severe LUTO who had either a primary composite outcome measure of neonatal death in the first 24 h of life due to severe pulmonary hypoplasia or a need for renal replacement therapy within 7 days of life. The following variables were analyzed: fetal bladder re-expansion 48 h after vesicocentesis, fetal renal ultrasound characteristics, fetal urinary indices, and amniotic fluid volume. Results: Of the 31 fetuses included in the study, eight met the criteria for ‘intrauterine fetal renal failure’. All of the latter had composite poor postnatal outcomes based on death within 24 h of life (n = 6) or need for dialysis within 1 week of life (n = 2). The percentage of fetal bladder refilling after vesicocentesis at time of initial evaluation was the only predictor of ‘intrauterine fetal renal failure’ (cut-off

Original languageEnglish (US)
Pages (from-to)605-612
Number of pages8
JournalPediatric Nephrology
Issue number4
StatePublished - Apr 1 2016


  • Fetal lower urinary tract obstruction
  • Fetal surgery
  • Posterior urethral valves
  • Prenatal diagnosis
  • Renal function
  • Ultrasonography
  • Vesicoamniotic shunt

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health


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