Defecatory function in Parkinson's disease: Response to apomorphine

L. L. Edwards, E. M.M. Quigley, R. K. Harned, Ruth Hofman, R. F. Pfeiffer

Research output: Contribution to journalArticlepeer-review

129 Scopus citations


We evaluated the effects of the dopaminergic agent apomorphine on defecation and anorectal function in patients with Parkinson's disease (PD). A gastrointestinal symptom survey, extrapyramidal assessment, defecating proctogram, and anorectal manometric study were performed in 8 subjects with PD. Basal studies showing abnormalities were repeated following apomorphine administration. Prior defecographic abnormalities were normalized following apomorphine injection in 1 of 3 subjects and significant improvements in manometric parameters were observed in all 5 subjects who underwent repeat anorectal manometry. We conclude that apomorphine can correct anorectal dysfunction in PD, and that these abnormalities may be a consequence of dopamine deficiency secondary to the PD process. These findings may also have therapeutic implications.

Original languageEnglish (US)
Pages (from-to)490-493
Number of pages4
JournalAnnals of Neurology
Issue number5
StatePublished - May 1993

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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