Deep-tissue imaging of intramolecular fluorescence resonance energy-transfer parameters

Vaibhav Gaind; Sumith Kularatne; Philip Low; Kevin J. Webb

doi:10.1364/OL.35.001314

Deep-tissue imaging of intramolecular fluorescence resonance energy-transfer parameters

Vaibhav Gaind, Sumith Kularatne, Philip Low, Kevin J. Webb

Houston Methodist

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

We demonstrate the in vivo reconstruction of all fluorescence resonance energy transfer (FRET) parameters, including the nanometer donor-acceptor distance, in a mouse. The FRET chemical targets cancer cells, and on internalization, the acceptor is released, in lieu of a targeted anticancer drug in chemotherapy. Our method provides a new vehicle for studying disease by imaging FRET parameters in deep tissue.

Original language	English (US)
Pages (from-to)	1314-1316
Number of pages	3
Journal	Optics Letters
Volume	35
Issue number	9
DOIs	https://doi.org/10.1364/OL.35.001314
State	Published - May 1 2010

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics

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10.1364/OL.35.001314

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title = "Deep-tissue imaging of intramolecular fluorescence resonance energy-transfer parameters",

abstract = "We demonstrate the in vivo reconstruction of all fluorescence resonance energy transfer (FRET) parameters, including the nanometer donor-acceptor distance, in a mouse. The FRET chemical targets cancer cells, and on internalization, the acceptor is released, in lieu of a targeted anticancer drug in chemotherapy. Our method provides a new vehicle for studying disease by imaging FRET parameters in deep tissue.",

author = "Vaibhav Gaind and Sumith Kularatne and Philip Low and Webb, \{Kevin J.\}",

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AU - Gaind, Vaibhav

AU - Kularatne, Sumith

AU - Low, Philip

AU - Webb, Kevin J.

PY - 2010/5/1

Y1 - 2010/5/1

N2 - We demonstrate the in vivo reconstruction of all fluorescence resonance energy transfer (FRET) parameters, including the nanometer donor-acceptor distance, in a mouse. The FRET chemical targets cancer cells, and on internalization, the acceptor is released, in lieu of a targeted anticancer drug in chemotherapy. Our method provides a new vehicle for studying disease by imaging FRET parameters in deep tissue.

AB - We demonstrate the in vivo reconstruction of all fluorescence resonance energy transfer (FRET) parameters, including the nanometer donor-acceptor distance, in a mouse. The FRET chemical targets cancer cells, and on internalization, the acceptor is released, in lieu of a targeted anticancer drug in chemotherapy. Our method provides a new vehicle for studying disease by imaging FRET parameters in deep tissue.

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DO - 10.1364/OL.35.001314

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SP - 1314

EP - 1316

JO - Optics Letters

JF - Optics Letters

IS - 9

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Deep-tissue imaging of intramolecular fluorescence resonance energy-transfer parameters

Abstract

ASJC Scopus subject areas

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