Deep-tissue imaging of intramolecular fluorescence resonance energy-transfer parameters

Vaibhav Gaind, Sumith Kularatne, Philip Low, Kevin J. Webb

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

We demonstrate the in vivo reconstruction of all fluorescence resonance energy transfer (FRET) parameters, including the nanometer donor-acceptor distance, in a mouse. The FRET chemical targets cancer cells, and on internalization, the acceptor is released, in lieu of a targeted anticancer drug in chemotherapy. Our method provides a new vehicle for studying disease by imaging FRET parameters in deep tissue.

Original languageEnglish (US)
Pages (from-to)1314-1316
Number of pages3
JournalOptics Letters
Volume35
Issue number9
DOIs
StatePublished - May 1 2010

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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