Abstract

For the last 50 years, levodopa has been the cornerstone of Parkinson's disease management. However, a majority of patients develop motor complications a few years after therapy onset. Deep brain stimulation has been approved by the FDA as an adjunctive treatment in Parkinson disease, especially aimed at controlling these complications. However, the exact mechanism of action of deep brain stimulation, the best nucleus to target as well as the best timing for surgery are still debatable. We here provide an in-depth and critical review of the current literature on this topic.

Original languageEnglish (US)
Article number22
JournalTranslational Neurodegeneration
Volume2
Issue number1
DOIs
StatePublished - Nov 18 2013

Keywords

  • Deep brain stimulation
  • Globus pallidus
  • Parkinson's disease
  • Subthalamic nucleus

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Cognitive Neuroscience

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