Dedifferentiated chondrosarcoma with a noncartilaginous component mimicking a conventional giant cell tumor of bone

Eréndira G. Estrada, Alberto G. Ayala, Lewis Valerie, Bogdan Czerniak

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

We report a case of dedifferentiated chondrosarcoma in which the dedifferentiated component of the tumor shows a close histologic resemblance to a conventional giant cell tumor of bone. The tumor affected a 30-year-old woman with a long history of left shoulder discomfort and limitation of motion. Radiographic studies revealed a biphasic destructive lesion in the left proximal humerus composed of high-signal lobulated component on T2-weighted magnetic resonance image accompanied by a low signal intensity component exhibiting destructive growth with extension into soft tissue. Microscopically, two different areas consisting of the chondroid tissue and nonchondroid giant cell-rich lesion resembling conventional giant cell tumor of bone were found. Considering that the prognosis and survival associated with these two entities are very different, it is important to be aware of this variant of dedifferentiated chondrosarcoma to avoid the misdiagnosis of conventional giant cell tumor of bone.

Original languageEnglish (US)
Pages (from-to)159-163
Number of pages5
JournalAnnals of Diagnostic Pathology
Volume6
Issue number3
DOIs
StatePublished - 2002

Keywords

  • Dedifferentiated chondrosarcoma with giant cell-like features

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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