Decreased virulence of a gls24 mutant of Enterococcus faecalis OG1RF in an experimental endocarditis model

Esteban C. Nannini, Fang Teng, Kavindra V. Singh, Barbara E. Murray

Research output: Contribution to journalArticlepeer-review

Abstract

In the current study, the gls24 disruption mutant TX10100, previously shown to be more sensitive to bile salts and attenuated in a mouse peritonitis model, showed an approximately fivefold higher 50% infective dose than wild-type OG1RF in a rat endocarditis model. When administered as a mixture, TX10100, unlike a downstream glsB mutant, was significantly outnumbered by OG1RF in vegetations, organs, and blood, despite being inoculated in greater numbers. These results indicate that gls24 is important in the pathogenesis of enterococcal endocarditis.

Original languageEnglish (US)
Pages (from-to)7772-7774
Number of pages3
JournalInfection and Immunity
Volume73
Issue number11
DOIs
StatePublished - Nov 2005

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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