TY - JOUR
T1 - Decreased virulence of a gls24 mutant of Enterococcus faecalis OG1RF in an experimental endocarditis model
AU - Nannini, Esteban C.
AU - Teng, Fang
AU - Singh, Kavindra V.
AU - Murray, Barbara E.
PY - 2005/11
Y1 - 2005/11
N2 - In the current study, the gls24 disruption mutant TX10100, previously shown to be more sensitive to bile salts and attenuated in a mouse peritonitis model, showed an approximately fivefold higher 50% infective dose than wild-type OG1RF in a rat endocarditis model. When administered as a mixture, TX10100, unlike a downstream glsB mutant, was significantly outnumbered by OG1RF in vegetations, organs, and blood, despite being inoculated in greater numbers. These results indicate that gls24 is important in the pathogenesis of enterococcal endocarditis.
AB - In the current study, the gls24 disruption mutant TX10100, previously shown to be more sensitive to bile salts and attenuated in a mouse peritonitis model, showed an approximately fivefold higher 50% infective dose than wild-type OG1RF in a rat endocarditis model. When administered as a mixture, TX10100, unlike a downstream glsB mutant, was significantly outnumbered by OG1RF in vegetations, organs, and blood, despite being inoculated in greater numbers. These results indicate that gls24 is important in the pathogenesis of enterococcal endocarditis.
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U2 - 10.1128/IAI.73.11.7772-7774.2005
DO - 10.1128/IAI.73.11.7772-7774.2005
M3 - Article
C2 - 16239583
AN - SCOPUS:27744505626
SN - 0019-9567
VL - 73
SP - 7772
EP - 7774
JO - Infection and Immunity
JF - Infection and Immunity
IS - 11
ER -