Decreased hypothalamic aromatization in female rats of true precocious puberty

Zhan Zhuang Tian; Hong Zhao; Bo Ying Chen

doi:10.1016/j.neulet.2004.05.012

Decreased hypothalamic aromatization in female rats of true precocious puberty

Zhan Zhuang Tian, Hong Zhao, Bo Ying Chen

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The true precocious puberty animal model induced by the single dose of danazol was used for investigating the expressions of hypothalamic aromatase in the advanced onset of puberty in rats. The day of vaginal opening and first estrus showed significant advancement in the model rats compared with the normal and vehicle rats (P < 0.01, respectively). The hypothalamic gonadotropin-releasing hormone (GnRH) mRNA expression increased significantly in the model rats compared with that in the normal and vehicle ones (P < 0.01). The levels of aromatase mRNA and protein expressions detected by RT-PCR and Western blot both decreased in the model rats compared with those in the normal and vehicle groups (P < 0.05). The results suggested that the hypothalamic aromatization might diminish in the onset of true precocious puberty of female rats.

Original language	English (US)
Pages (from-to)	92-96
Number of pages	5
Journal	Neuroscience Letters
Volume	366
Issue number	1
DOIs	https://doi.org/10.1016/j.neulet.2004.05.012
State	Published - Aug 5 2004

Keywords

Aromatase
Danazol
Female rats
Gonadotropin-releasing hormone (GnRH)
True precocious puberty

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.neulet.2004.05.012

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@article{f808e8783e364aac9ea36f3e2da00951,

title = "Decreased hypothalamic aromatization in female rats of true precocious puberty",

abstract = "The true precocious puberty animal model induced by the single dose of danazol was used for investigating the expressions of hypothalamic aromatase in the advanced onset of puberty in rats. The day of vaginal opening and first estrus showed significant advancement in the model rats compared with the normal and vehicle rats (P < 0.01, respectively). The hypothalamic gonadotropin-releasing hormone (GnRH) mRNA expression increased significantly in the model rats compared with that in the normal and vehicle ones (P < 0.01). The levels of aromatase mRNA and protein expressions detected by RT-PCR and Western blot both decreased in the model rats compared with those in the normal and vehicle groups (P < 0.05). The results suggested that the hypothalamic aromatization might diminish in the onset of true precocious puberty of female rats.",

keywords = "Aromatase, Danazol, Female rats, Gonadotropin-releasing hormone (GnRH), True precocious puberty",

author = "Tian, {Zhan Zhuang} and Hong Zhao and Chen, {Bo Ying}",

note = "Funding Information: This project was supported by the Research Fund for Doctoral Program of Higher Education (grant no. 20010246008). Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

year = "2004",

month = aug,

day = "5",

doi = "10.1016/j.neulet.2004.05.012",

language = "English (US)",

volume = "366",

pages = "92--96",

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T1 - Decreased hypothalamic aromatization in female rats of true precocious puberty

AU - Tian, Zhan Zhuang

AU - Zhao, Hong

AU - Chen, Bo Ying

N1 - Funding Information: This project was supported by the Research Fund for Doctoral Program of Higher Education (grant no. 20010246008). Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2004/8/5

Y1 - 2004/8/5

N2 - The true precocious puberty animal model induced by the single dose of danazol was used for investigating the expressions of hypothalamic aromatase in the advanced onset of puberty in rats. The day of vaginal opening and first estrus showed significant advancement in the model rats compared with the normal and vehicle rats (P < 0.01, respectively). The hypothalamic gonadotropin-releasing hormone (GnRH) mRNA expression increased significantly in the model rats compared with that in the normal and vehicle ones (P < 0.01). The levels of aromatase mRNA and protein expressions detected by RT-PCR and Western blot both decreased in the model rats compared with those in the normal and vehicle groups (P < 0.05). The results suggested that the hypothalamic aromatization might diminish in the onset of true precocious puberty of female rats.

AB - The true precocious puberty animal model induced by the single dose of danazol was used for investigating the expressions of hypothalamic aromatase in the advanced onset of puberty in rats. The day of vaginal opening and first estrus showed significant advancement in the model rats compared with the normal and vehicle rats (P < 0.01, respectively). The hypothalamic gonadotropin-releasing hormone (GnRH) mRNA expression increased significantly in the model rats compared with that in the normal and vehicle ones (P < 0.01). The levels of aromatase mRNA and protein expressions detected by RT-PCR and Western blot both decreased in the model rats compared with those in the normal and vehicle groups (P < 0.05). The results suggested that the hypothalamic aromatization might diminish in the onset of true precocious puberty of female rats.

KW - Aromatase

KW - Danazol

KW - Female rats

KW - Gonadotropin-releasing hormone (GnRH)

KW - True precocious puberty

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ER -

Decreased hypothalamic aromatization in female rats of true precocious puberty

Abstract

Keywords

ASJC Scopus subject areas

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