Deciphering modular and dynamic behaviors of transcriptional networks

Ming Zhan

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

The coordinated and dynamic modulation or interaction of genes or proteins acts as an important mechanism used by a cell in functional regulation. Recent studies have shown that many transcriptional networks exhibit a scale-free topology and hierarchical modular architecture. It has also been shown that transcriptional networks or pathways are dynamic and behave only in certain ways and controlled manners in response to disease development, changing cellular conditions, and different environmental factors. Moreover, evolutionarily conserved and divergent transcriptional modules underline fundamental and species-specific molecular mechanisms controlling disease development or cellular phenotypes. Various computational algorithms have been developed to explore transcriptional networks and modules from gene expression data. In silico studies have also been made to mimic the dynamic behavior of regulatory networks, analyzing how disease or cellular phenotypes arise from the connectivity or networks of genes and their products. Here, we review the recent development in computational biology research on deciphering modular and dynamic behaviors of transcriptional networks, highlighting important findings. We also demonstrate how these computational algorithms can be applied in systems biology studies as on disease, stem cells, and drug discovery.

Original languageEnglish (US)
Pages (from-to)19-28
Number of pages10
JournalGenomic Medicine
Volume1
Issue number1-2
DOIs
StatePublished - Sep 2007

Keywords

  • Coexpression
  • ModulePro
  • Pathway dynamics
  • PathwayPro
  • Systems biology
  • Transcriptional intervention
  • Transcriptional module

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

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