TY - JOUR
T1 - Deceased Donor Predictors for Pediatric Liver Allograft Utilization
AU - Xie, Rongxing
AU - Huang, Shanzhou
AU - Sun, Chengjun
AU - Zhu, Zebin
AU - Tang, Yunhua
AU - Zhao, Qiang
AU - Guo, Zhiyong
AU - He, Xiaoshun
AU - Ju, Weiqiang
N1 - Funding Information:
This study was supported by the National Key Technologies R&D Program (No. 2015BAI13B09), the National Natural Science Foundation of China (81373156, 81471583 and 81570587), Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation) (2015B050501002), Guangdong Provincial Natural Science Funds for Major Basic Science Culture Projects (2015A030308010), Guangdong Provincial Natural Science Funds for Distinguished Young Scholars (2015A030306025), special support program for training high-level talent in Guangdong Province (2015TQ01R168), Pearl River Nova Program of Guangzhou (201506010014), and the Science and Technology Program of Guangzhou (201704020150).
Funding Information:
This study was supported by the National Key Technologies R&D Program (No. 2015BAI13B09), the National Natural Science Foundation of China ( 81373156 , 81471583 and 81570587 ), Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation) ( 2015B050501002 ), Guangdong Provincial Natural Science Funds for Major Basic Science Culture Projects ( 2015A030308010 ), Guangdong Provincial Natural Science Funds for Distinguished Young Scholars ( 2015A030306025 ), special support program for training high-level talent in Guangdong Province ( 2015TQ01R168 ), Pearl River Nova Program of Guangzhou ( 201506010014 ), and the Science and Technology Program of Guangzhou ( 201704020150 ).
Publisher Copyright:
© 2020
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/12
Y1 - 2020/12
N2 - BACKGROUND: The number of pediatric deceased organ donors has recently declined, and the nonutilization of pediatric liver allografts has limited the development of liver transplantation. We determined the utilization rate of pediatric livers and identified risk factors for graft discard.METHODS: We used data from the Scientific Registry of Transplant Recipients database from January 1, 2000, to December 31, 2012. The trends of pediatric liver donors and utilization rates were analyzed. Donor risk factors that impacted the graft use of pediatric livers were measured. Logistic regression modelling was performed to evaluate graft utilization and risk factors.RESULTS: A total of 11,934 eligible pediatric liver donors were identified during this period. A total of 1191 authorized liver grafts did not recover or recovered without transplantation. Factors including pediatric donors >1 year of age (odds ratio [OR] = 2.956, 95% confidence interval [CI] 2.494-3.503, P < .001), nonhead trauma (OR = 2.243, 95% CI 1.903-2.642, P < .001), lack of heartbeat (OR = 7.534, 95% CI 5.899-9.623, P < .001), hepatitis B surface antigen positivity (OR = 4.588, 95% CI 1.021-20.625, P = .047), anti-hepatitis C virus positivity (OR = 4.691, 95% CI 1.352-16.280, P = .015), total bilirubin >1 mg/dL (OR = 1.743, 95% CI 1.469-2.068, P < .001), and blood urea nitrogen >21 mg/dL (OR = 1.941, 95% CI 1.546-2.436, P < .001) were significantly related to graft nonutilization. Steroids or diuretics administered prerecovery were significantly related to graft utilization (OR = 0.684, 95% CI 0.581-0.806, P < .001; OR = 0.744, 95% CI 0.634-0.874, P < .001; respectively).CONCLUSIONS: The pediatric liver allograft utilization rate and risk factors for nonutilization of grafts were determined.
AB - BACKGROUND: The number of pediatric deceased organ donors has recently declined, and the nonutilization of pediatric liver allografts has limited the development of liver transplantation. We determined the utilization rate of pediatric livers and identified risk factors for graft discard.METHODS: We used data from the Scientific Registry of Transplant Recipients database from January 1, 2000, to December 31, 2012. The trends of pediatric liver donors and utilization rates were analyzed. Donor risk factors that impacted the graft use of pediatric livers were measured. Logistic regression modelling was performed to evaluate graft utilization and risk factors.RESULTS: A total of 11,934 eligible pediatric liver donors were identified during this period. A total of 1191 authorized liver grafts did not recover or recovered without transplantation. Factors including pediatric donors >1 year of age (odds ratio [OR] = 2.956, 95% confidence interval [CI] 2.494-3.503, P < .001), nonhead trauma (OR = 2.243, 95% CI 1.903-2.642, P < .001), lack of heartbeat (OR = 7.534, 95% CI 5.899-9.623, P < .001), hepatitis B surface antigen positivity (OR = 4.588, 95% CI 1.021-20.625, P = .047), anti-hepatitis C virus positivity (OR = 4.691, 95% CI 1.352-16.280, P = .015), total bilirubin >1 mg/dL (OR = 1.743, 95% CI 1.469-2.068, P < .001), and blood urea nitrogen >21 mg/dL (OR = 1.941, 95% CI 1.546-2.436, P < .001) were significantly related to graft nonutilization. Steroids or diuretics administered prerecovery were significantly related to graft utilization (OR = 0.684, 95% CI 0.581-0.806, P < .001; OR = 0.744, 95% CI 0.634-0.874, P < .001; respectively).CONCLUSIONS: The pediatric liver allograft utilization rate and risk factors for nonutilization of grafts were determined.
KW - Adolescent
KW - Allografts/supply & distribution
KW - Child
KW - Child, Preschool
KW - Female
KW - Humans
KW - Infant
KW - Liver Transplantation
KW - Male
KW - Risk Factors
KW - Tissue Donors/supply & distribution
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U2 - 10.1016/j.transproceed.2020.05.010
DO - 10.1016/j.transproceed.2020.05.010
M3 - Article
C2 - 32718748
AN - SCOPUS:85088587220
VL - 52
SP - 2901
EP - 2908
JO - Transplantation Proceedings
JF - Transplantation Proceedings
SN - 0041-1345
IS - 10
ER -