Daptomycin for the treatment of bacteraemia due to vancomycin-resistant enterococci

Jose M. Munita, Barbara E. Murray, Cesar A. Arias

Research output: Contribution to journalReview articlepeer-review

Abstract

Treatment of severe infections caused by vancomycin-resistant enterococci (VRE) is challenging due to the scarcity of reliable therapeutic alternatives. In this context, daptomycin (DAP), a lipopeptide antibiotic, has emerged as an interesting alternative as it is one of the few compounds that retain in vitro bactericidal activity against VRE isolates, although it has not been approved for this purpose by regulatory agencies. In this review, we will summarise the clinical, animal and in vitro evidence evaluating the efficacy of DAP for the management of deep-seated VRE infections. In addition, we will address important clinical concerns such as the emergence of DAP resistance during therapy and reports of therapeutic failure with DAP monotherapy. Finally, we will discuss possible future strategies (such as the use of higher doses and/or combination therapies) to optimise the use of this antibiotic against VRE.

Original languageEnglish (US)
Pages (from-to)387-395
Number of pages9
JournalInternational Journal of Antimicrobial Agents
Volume44
Issue number5
DOIs
StatePublished - Sep 2 2014

Keywords

  • Daptomycin
  • Enterococcal bacteraemia
  • Enterococci
  • VRE

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

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