Dandy-Walker syndrome presenting as opisthotonus: Proposed pathophysiology

William G. Ondo, G. Robert Delong

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


A patient with radiographically confirmed Dandy-Walker syndrome who presented with opisthotonus, a rarely reported clinical manifestation, is reported. From four separate pharmacologic trials (baclofen, diazepam, levodopa/carbidopa, and trihexyphenidyl), combination baclofen and diazepam therapy was determined to be most efficacious. Opisthotonus and extensor posturing remain only rudimentarily understood. We review the subject and propose a specific mechanism relating our patient's anatomic and physiologic conditions.

Original languageEnglish (US)
Pages (from-to)165-168
Number of pages4
JournalPediatric Neurology
Issue number2
StatePublished - Jan 1 1996

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology


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