Dandy-Walker syndrome presenting as opisthotonus: Proposed pathophysiology

William G. Ondo; G. Robert Delong

doi:10.1016/0887-8994(96)00014-8

Dandy-Walker syndrome presenting as opisthotonus: Proposed pathophysiology

William G. Ondo, G. Robert Delong

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

A patient with radiographically confirmed Dandy-Walker syndrome who presented with opisthotonus, a rarely reported clinical manifestation, is reported. From four separate pharmacologic trials (baclofen, diazepam, levodopa/carbidopa, and trihexyphenidyl), combination baclofen and diazepam therapy was determined to be most efficacious. Opisthotonus and extensor posturing remain only rudimentarily understood. We review the subject and propose a specific mechanism relating our patient's anatomic and physiologic conditions.

Original language	English (US)
Pages (from-to)	165-168
Number of pages	4
Journal	Pediatric Neurology
Volume	14
Issue number	2
DOIs	https://doi.org/10.1016/0887-8994(96)00014-8
State	Published - Jan 1 1996

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Neurology
Developmental Neuroscience
Clinical Neurology

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10.1016/0887-8994(96)00014-8

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abstract = "A patient with radiographically confirmed Dandy-Walker syndrome who presented with opisthotonus, a rarely reported clinical manifestation, is reported. From four separate pharmacologic trials (baclofen, diazepam, levodopa/carbidopa, and trihexyphenidyl), combination baclofen and diazepam therapy was determined to be most efficacious. Opisthotonus and extensor posturing remain only rudimentarily understood. We review the subject and propose a specific mechanism relating our patient's anatomic and physiologic conditions.",

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AU - Delong, G. Robert

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N2 - A patient with radiographically confirmed Dandy-Walker syndrome who presented with opisthotonus, a rarely reported clinical manifestation, is reported. From four separate pharmacologic trials (baclofen, diazepam, levodopa/carbidopa, and trihexyphenidyl), combination baclofen and diazepam therapy was determined to be most efficacious. Opisthotonus and extensor posturing remain only rudimentarily understood. We review the subject and propose a specific mechanism relating our patient's anatomic and physiologic conditions.

AB - A patient with radiographically confirmed Dandy-Walker syndrome who presented with opisthotonus, a rarely reported clinical manifestation, is reported. From four separate pharmacologic trials (baclofen, diazepam, levodopa/carbidopa, and trihexyphenidyl), combination baclofen and diazepam therapy was determined to be most efficacious. Opisthotonus and extensor posturing remain only rudimentarily understood. We review the subject and propose a specific mechanism relating our patient's anatomic and physiologic conditions.

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Dandy-Walker syndrome presenting as opisthotonus: Proposed pathophysiology

Abstract

ASJC Scopus subject areas

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