Abstract
Ropinirole, a D2/D3 receptor agonist has been reported to have neuroprotective effects. We showed that ropinirole can prevent rotenone-induced apoptosis in dopaminergic cell line SH-SY5Y through D3 receptor. We found that ropinirole can block the rotenone-induced phosphorylation of JNK, P38 and p-c-Jun, but promote the phosphorylation of ERK1/2. Furthermore, we demonstrated that ropinirole can reduce the rotenone-induced cleavages of caspase 9, caspase 3 and PARP and elevate the expression of anti-apoptotic proteins of p-Akt and bcl-2. These results provide a basis for neuroprotection by this drug for the treatment of Parkinson disease.
Original language | English (US) |
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Pages (from-to) | 603-610 |
Number of pages | 8 |
Journal | FEBS Letters |
Volume | 582 |
Issue number | 5 |
DOIs | |
State | Published - Mar 5 2008 |
Keywords
- Apoptosis
- MAP-kinase
- Parkinson disease
- Ropinirole
- Rotenone
- SH-SY5Y cell line
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology