D2/D3 receptor agonist ropinirole protects dopaminergic cell line against rotenone-induced apoptosis through inhibition of caspase- and JNK-dependent pathways

Sheng Chen, Xiaojie Zhang, Dehua Yang, Yunlan Du, Liang Li, Xuping Li, Ming Ming, Weidong Le

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

Ropinirole, a D2/D3 receptor agonist has been reported to have neuroprotective effects. We showed that ropinirole can prevent rotenone-induced apoptosis in dopaminergic cell line SH-SY5Y through D3 receptor. We found that ropinirole can block the rotenone-induced phosphorylation of JNK, P38 and p-c-Jun, but promote the phosphorylation of ERK1/2. Furthermore, we demonstrated that ropinirole can reduce the rotenone-induced cleavages of caspase 9, caspase 3 and PARP and elevate the expression of anti-apoptotic proteins of p-Akt and bcl-2. These results provide a basis for neuroprotection by this drug for the treatment of Parkinson disease.

Original languageEnglish (US)
Pages (from-to)603-610
Number of pages8
JournalFEBS Letters
Volume582
Issue number5
DOIs
StatePublished - Mar 5 2008

Keywords

  • Apoptosis
  • MAP-kinase
  • Parkinson disease
  • Ropinirole
  • Rotenone
  • SH-SY5Y cell line

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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