D Glucose enhancement of water reabsorption in proximal tubule of the rat kidney

E. J. Weinman, Wadi N. Suki, G. Eknoyan

Research output: Chapter in Book/Report/Conference proceedingChapter

12 Scopus citations


Water reabsorption in the proximal convoluted tubule of the rat kidney was examined by in vivo microperfusion techniques in order to examine the effect of D glucose within the tubular lumen. When tubules were perfused with a balanced artificial solution containing Na, K, Cl, HCO3, urea, and D glucose, absolute reabsorption averaged 4.01±0.24 nl/min per mm tubule length. Perfusion with isotonic NaCl resulted in a 37% decrease in reabsorption of 2.54±0.17 nl/min per mm. Addition of D glucose to the NaCl perfusate enhanced water reabsorption to values similar to those obtained with the balanced artificial perfusate. The enhanced water reabsorption consequent to the addition of D glucose to the NaCl perfusion solution was completely inhibited by addition of phloridzin to the perfusate. The addition of an unabsorbed hexose, 2 deoxy D glucose, to the NaCl perfusate failed to enhance water reabsorption, whereas the addition of an incompletely reabsorbed sugar that is not metabolized, 3 O methyl D glucose, resulted in partial enhancement of the absolute rate of water reabsorption. These studies demonstrate that D glucose has the specific effect of augmenting water reabsorption in the proximal tubule of the rat kidney.

Original languageEnglish
Title of host publicationAmerican Journal of Physiology
Number of pages4
StatePublished - Dec 1 1976

ASJC Scopus subject areas

  • Medicine(all)


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