Cytotoxic T-lymphocyte antigen-4 microsatellite polymorphism is associated with multiple myeloma

Chengyun Zheng, De Ren Huang, Li Liu, Magnus Björkholm, Göran Holm, Qing Yi, Anne Sundblad

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Multiple myeloma (MM) is a B-lineage malignancy with unknown aetiology. It has been considered that predisposing genetic factors might be implicated in the disease. In this study, the microsatellite polymorphism in the exon 3 of the cytotoxic T-lymphocyte antigen-4 (CTLA-4) gene was analysed in patients with MM and monoclonal gammopathy of undetermined significance (MGUS), together with ethnically matched healthy controls. The results showed that frequencies of the genotype 86/86 and of the allele 86 were significantly decreased in MM and MGUS compared with matched healthy controls, indicating that the CTLA-4 microsatellite polymorphism might represent a susceptibility locus for MM and MGUS.

Original languageEnglish (US)
Pages (from-to)216-218
Number of pages3
JournalBritish Journal of Haematology
Volume112
Issue number1
DOIs
StatePublished - 2001

Keywords

  • CTLA-4 gene
  • Multiple myeloma
  • Polymorphism

ASJC Scopus subject areas

  • Hematology

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