Abstract
Multiple myeloma (MM) is a B-lineage malignancy with unknown aetiology. It has been considered that predisposing genetic factors might be implicated in the disease. In this study, the microsatellite polymorphism in the exon 3 of the cytotoxic T-lymphocyte antigen-4 (CTLA-4) gene was analysed in patients with MM and monoclonal gammopathy of undetermined significance (MGUS), together with ethnically matched healthy controls. The results showed that frequencies of the genotype 86/86 and of the allele 86 were significantly decreased in MM and MGUS compared with matched healthy controls, indicating that the CTLA-4 microsatellite polymorphism might represent a susceptibility locus for MM and MGUS.
Original language | English (US) |
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Pages (from-to) | 216-218 |
Number of pages | 3 |
Journal | British Journal of Haematology |
Volume | 112 |
Issue number | 1 |
DOIs | |
State | Published - 2001 |
Keywords
- CTLA-4 gene
- Multiple myeloma
- Polymorphism
ASJC Scopus subject areas
- Hematology