Cytotoxic drug-induced lung disease

Henry Dirk Sostman, Richard A. Matthay, Charles E. Putman

Research output: Contribution to journalReview articlepeer-review

103 Scopus citations


Cytotoxic drugs, principally bleomycin, methotrexate and busulfan, have been associated with pulmonary toxicity. Cytotoxic drug-induced lung disease may be difficult to establish with certainty because other causes of pulmonary disease are frequently present. We discuss the clinical, roentgenographic and histologic effects of the administration of bleomycin, methotrexate, busulfan and other cytotoxic agents on the lungs and suggest that these agents may also cause pulmonary malignancies. We note the importance of careful patient monitoring and withdrawal of a demonstrated offending agent.

Original languageEnglish (US)
Pages (from-to)608-615
Number of pages8
JournalThe American journal of medicine
Issue number4
StatePublished - Jan 1 1977

ASJC Scopus subject areas

  • Medicine(all)


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