Cytomegalovirus pneumonia in adult nontransplantation patients with cancer: Review of 20 cases occurring from 1964 through 1990

Jorge R. Mera; Estella Whimbey; Linda Elting; Alejandro Preti; Mario A. Luna; Janet M. Bruner; Temple Williams; Gerald P. Bodey; James M. Goodrich

doi:10.1093/clinids/22.6.1046

Cytomegalovirus pneumonia in adult nontransplantation patients with cancer: Review of 20 cases occurring from 1964 through 1990

Jorge R. Mera, Estella Whimbey, Linda Elting, Alejandro Preti, Mario A. Luna, Janet M. Bruner, Temple Williams, Gerald P. Bodey, James M. Goodrich

Academic Institute

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Abstract

The objectives of this study were to estimate the frequency of cytomegalovirus (CMV) pneumonia and describe its clinical and radiological presentation in adult nontransplantation patients with cancer. Of the 10,441 autopsies performed at M.D. Anderson Cancer Center (Houston) during the period of January 1964 through December 1990, 9,029 were evaluable. Twenty histopathologically confirmed cases of CMV pneumonia were found, representing a frequency of 2.2 cases per 1,000 autopsies. When the frequency of CMV pneumonia was compared for the periods 1964-1979 (1.5 cases per 1.000 autopsies) and 1980-1990 (4.6 cases per 1,000 autopsies), a statistically significant increase due to an increase in the number of patients with solid malignancies was observed (P < .05). CMV pneumonia is an uncommon diagnosis at autopsy for adult nontransplantation patients with cancer and is usually found in conjunction with a disseminated neoplastic process.

Original language	English (US)
Pages (from-to)	1046-1050
Number of pages	5
Journal	Clinical Infectious Diseases
Volume	22
Issue number	6
DOIs	https://doi.org/10.1093/clinids/22.6.1046
State	Published - 1996

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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title = "Cytomegalovirus pneumonia in adult nontransplantation patients with cancer: Review of 20 cases occurring from 1964 through 1990",

abstract = "The objectives of this study were to estimate the frequency of cytomegalovirus (CMV) pneumonia and describe its clinical and radiological presentation in adult nontransplantation patients with cancer. Of the 10,441 autopsies performed at M.D. Anderson Cancer Center (Houston) during the period of January 1964 through December 1990, 9,029 were evaluable. Twenty histopathologically confirmed cases of CMV pneumonia were found, representing a frequency of 2.2 cases per 1,000 autopsies. When the frequency of CMV pneumonia was compared for the periods 1964-1979 (1.5 cases per 1.000 autopsies) and 1980-1990 (4.6 cases per 1,000 autopsies), a statistically significant increase due to an increase in the number of patients with solid malignancies was observed (P < .05). CMV pneumonia is an uncommon diagnosis at autopsy for adult nontransplantation patients with cancer and is usually found in conjunction with a disseminated neoplastic process.",

author = "Mera, {Jorge R.} and Estella Whimbey and Linda Elting and Alejandro Preti and Luna, {Mario A.} and Bruner, {Janet M.} and Temple Williams and Bodey, {Gerald P.} and Goodrich, {James M.}",

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AU - Mera, Jorge R.

AU - Whimbey, Estella

AU - Elting, Linda

AU - Preti, Alejandro

AU - Luna, Mario A.

AU - Bruner, Janet M.

AU - Williams, Temple

AU - Bodey, Gerald P.

AU - Goodrich, James M.

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N2 - The objectives of this study were to estimate the frequency of cytomegalovirus (CMV) pneumonia and describe its clinical and radiological presentation in adult nontransplantation patients with cancer. Of the 10,441 autopsies performed at M.D. Anderson Cancer Center (Houston) during the period of January 1964 through December 1990, 9,029 were evaluable. Twenty histopathologically confirmed cases of CMV pneumonia were found, representing a frequency of 2.2 cases per 1,000 autopsies. When the frequency of CMV pneumonia was compared for the periods 1964-1979 (1.5 cases per 1.000 autopsies) and 1980-1990 (4.6 cases per 1,000 autopsies), a statistically significant increase due to an increase in the number of patients with solid malignancies was observed (P < .05). CMV pneumonia is an uncommon diagnosis at autopsy for adult nontransplantation patients with cancer and is usually found in conjunction with a disseminated neoplastic process.

AB - The objectives of this study were to estimate the frequency of cytomegalovirus (CMV) pneumonia and describe its clinical and radiological presentation in adult nontransplantation patients with cancer. Of the 10,441 autopsies performed at M.D. Anderson Cancer Center (Houston) during the period of January 1964 through December 1990, 9,029 were evaluable. Twenty histopathologically confirmed cases of CMV pneumonia were found, representing a frequency of 2.2 cases per 1,000 autopsies. When the frequency of CMV pneumonia was compared for the periods 1964-1979 (1.5 cases per 1.000 autopsies) and 1980-1990 (4.6 cases per 1,000 autopsies), a statistically significant increase due to an increase in the number of patients with solid malignancies was observed (P < .05). CMV pneumonia is an uncommon diagnosis at autopsy for adult nontransplantation patients with cancer and is usually found in conjunction with a disseminated neoplastic process.

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Cytomegalovirus pneumonia in adult nontransplantation patients with cancer: Review of 20 cases occurring from 1964 through 1990

Abstract

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