Cytological and histological changes in the middle ear after inoculation of influenza a virus

M. H. Chung, S. R. Griffith, K. H. Park, David J. Lim, T. F. Demaria

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Experimental otitis media induced in the chinchilla by inoculation of influenza A virus into the middle ear resulted in capillary engorgement, subepithelial hemorrhage, tissue edema and acute inflammatory cell infiltration. Quantitative morphometric measurements were made for 28 days. Ciliated cells appeared to be the primary target of this strain of influenza virus and demonstrated the greatest degree of damage. Three weeks were required to restore the ciliated epithelium in the tubotympanum to normal levels.

Original languageEnglish (US)
Pages (from-to)81-87
Number of pages7
JournalActa Oto-Laryngologica
Volume113
Issue number1-2
DOIs
StatePublished - Jan 1 1993

Keywords

  • Chinchilla
  • Ciliated cells
  • Middle ear
  • Otitis media
  • Respiratory tract virus

ASJC Scopus subject areas

  • Otorhinolaryngology

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