TY - JOUR
T1 - Cytokines in heart failure
T2 - Pathogenetic mechanisms and potential treatment
AU - Dibbs, Z.
AU - Kurrelmeyer, K.
AU - Kalra, D.
AU - Seta, Y.
AU - Wang, F.
AU - Bozkurt, B.
AU - Baumgarten, G.
AU - Sivasubramanian, N.
AU - Mann, D. L.
PY - 1999
Y1 - 1999
N2 - Recent studies have shown that patients with heart failure overexpress a class of biologically active molecules, generically referred to as pro- inflammatory cytokines. This article will review recent clinical and experimental material that suggests that pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), and interleukin-6 (IL-6) may play a role in the pathogenesis of congestive heart failure. In addition, we will review recent studies that suggest that antagonizing cytokines may represent a novel target for heart failure therapy.
AB - Recent studies have shown that patients with heart failure overexpress a class of biologically active molecules, generically referred to as pro- inflammatory cytokines. This article will review recent clinical and experimental material that suggests that pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), and interleukin-6 (IL-6) may play a role in the pathogenesis of congestive heart failure. In addition, we will review recent studies that suggest that antagonizing cytokines may represent a novel target for heart failure therapy.
KW - Cardiomyopathy
KW - Interleukin-1
KW - Interleukin-6
KW - Left ventricular remodeling
KW - Tumor necrosis factor-α
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U2 - 10.1111/paa.1999.111.5.423
DO - 10.1111/paa.1999.111.5.423
M3 - Review article
C2 - 10519163
AN - SCOPUS:0032858469
VL - 111
SP - 423
EP - 428
JO - Proceedings of the Association of American Physicians
JF - Proceedings of the Association of American Physicians
SN - 1081-650X
IS - 5
ER -