Recent studies have shown that patients with heart failure overexpress a class of biologically active molecules, generically referred to as pro- inflammatory cytokines. This article will review recent clinical and experimental material that suggests that pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), and interleukin-6 (IL-6) may play a role in the pathogenesis of congestive heart failure. In addition, we will review recent studies that suggest that antagonizing cytokines may represent a novel target for heart failure therapy.
|Original language||English (US)|
|Number of pages||6|
|Journal||Proceedings of the Association of American Physicians|
|State||Published - 1999|
- Left ventricular remodeling
- Tumor necrosis factor-α
ASJC Scopus subject areas