Cytokines in heart failure: Pathogenetic mechanisms and potential treatment

Z. Dibbs; K. Kurrelmeyer; D. Kalra; Y. Seta; F. Wang; B. Bozkurt; G. Baumgarten; N. Sivasubramanian; D. L. Mann

doi:10.1111/paa.1999.111.5.423

Cytokines in heart failure: Pathogenetic mechanisms and potential treatment

Z. Dibbs, K. Kurrelmeyer, D. Kalra, Y. Seta, F. Wang, B. Bozkurt, G. Baumgarten, N. Sivasubramanian, D. L. Mann

Research output: Contribution to journal › Review article › peer-review

61 Scopus citations

Abstract

Recent studies have shown that patients with heart failure overexpress a class of biologically active molecules, generically referred to as pro- inflammatory cytokines. This article will review recent clinical and experimental material that suggests that pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), and interleukin-6 (IL-6) may play a role in the pathogenesis of congestive heart failure. In addition, we will review recent studies that suggest that antagonizing cytokines may represent a novel target for heart failure therapy.

Original language	English (US)
Pages (from-to)	423-428
Number of pages	6
Journal	Proceedings of the Association of American Physicians
Volume	111
Issue number	5
DOIs	https://doi.org/10.1111/paa.1999.111.5.423
State	Published - 1999

Keywords

Cardiomyopathy
Interleukin-1
Interleukin-6
Left ventricular remodeling
Tumor necrosis factor-α

ASJC Scopus subject areas

General Medicine

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10.1111/paa.1999.111.5.423

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title = "Cytokines in heart failure: Pathogenetic mechanisms and potential treatment",

abstract = "Recent studies have shown that patients with heart failure overexpress a class of biologically active molecules, generically referred to as pro- inflammatory cytokines. This article will review recent clinical and experimental material that suggests that pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), and interleukin-6 (IL-6) may play a role in the pathogenesis of congestive heart failure. In addition, we will review recent studies that suggest that antagonizing cytokines may represent a novel target for heart failure therapy.",

keywords = "Cardiomyopathy, Interleukin-1, Interleukin-6, Left ventricular remodeling, Tumor necrosis factor-α",

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T1 - Cytokines in heart failure

T2 - Pathogenetic mechanisms and potential treatment

AU - Dibbs, Z.

AU - Kurrelmeyer, K.

AU - Kalra, D.

AU - Seta, Y.

AU - Wang, F.

AU - Bozkurt, B.

AU - Baumgarten, G.

AU - Sivasubramanian, N.

AU - Mann, D. L.

PY - 1999

Y1 - 1999

N2 - Recent studies have shown that patients with heart failure overexpress a class of biologically active molecules, generically referred to as pro- inflammatory cytokines. This article will review recent clinical and experimental material that suggests that pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), and interleukin-6 (IL-6) may play a role in the pathogenesis of congestive heart failure. In addition, we will review recent studies that suggest that antagonizing cytokines may represent a novel target for heart failure therapy.

AB - Recent studies have shown that patients with heart failure overexpress a class of biologically active molecules, generically referred to as pro- inflammatory cytokines. This article will review recent clinical and experimental material that suggests that pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), and interleukin-6 (IL-6) may play a role in the pathogenesis of congestive heart failure. In addition, we will review recent studies that suggest that antagonizing cytokines may represent a novel target for heart failure therapy.

KW - Cardiomyopathy

KW - Interleukin-1

KW - Interleukin-6

KW - Left ventricular remodeling

KW - Tumor necrosis factor-α

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JO - Proceedings of the Association of American Physicians

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Cytokines in heart failure: Pathogenetic mechanisms and potential treatment

Abstract

Keywords

ASJC Scopus subject areas

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