Abstract
Recent studies have shown that patients with heart failure overexpress a class of biologically active molecules, generically referred to as pro- inflammatory cytokines. This article will review recent clinical and experimental material that suggests that pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), and interleukin-6 (IL-6) may play a role in the pathogenesis of congestive heart failure. In addition, we will review recent studies that suggest that antagonizing cytokines may represent a novel target for heart failure therapy.
Original language | English (US) |
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Pages (from-to) | 423-428 |
Number of pages | 6 |
Journal | Proceedings of the Association of American Physicians |
Volume | 111 |
Issue number | 5 |
DOIs | |
State | Published - 1999 |
Keywords
- Cardiomyopathy
- Interleukin-1
- Interleukin-6
- Left ventricular remodeling
- Tumor necrosis factor-α
ASJC Scopus subject areas
- General Medicine