Cytokines and the microcirculation in ischemia and reperfusion

Nikolaos G. Frangogiannis, Keith A. Youker, Roger D. Rossen, Marianne Gwechenberger, Merry H. Lindsey, Leonardo H. Mendoza, Lloyd H. Michael, Christie M. Ballantyne, C. Wayne Smith, Mark L. Entman

Research output: Contribution to journalArticlepeer-review

177 Scopus citations


The intense inflammatory reaction following reperfusion of the infarcted myocardium has been implicated as a factor in extension of injury. However, this inflammatory reaction is also critical to tissue repair. The cellular responses that mediate these functions are orchestrated by sequential induction and/or release of cytokines resulting in a closely regulated cytokine cascade. This paper reviews research on these cytokine cascades, their cellular origin, and factors which control the cellular response to their presence. Factors examined include leukotaxis, phenotypic transition of leukocytes, adhesion molecule induction and the role of cytokines in tissue repair and scar formation.

Original languageEnglish (US)
Pages (from-to)2567-2576
Number of pages10
JournalJournal of Molecular and Cellular Cardiology
Issue number12
StatePublished - Dec 1998


  • Cardiac tissue repair
  • Cytokines
  • Inflammation
  • Leukocytes
  • Reperfusion injury

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine


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