Cytokines and the microcirculation in ischemia and reperfusion

Nikolaos G. Frangogiannis; Keith A. Youker; Roger D. Rossen; Marianne Gwechenberger; Merry H. Lindsey; Leonardo H. Mendoza; Lloyd H. Michael; Christie M. Ballantyne; C. Wayne Smith; Mark L. Entman

doi:10.1006/jmcc.1998.0829

Cytokines and the microcirculation in ischemia and reperfusion

Nikolaos G. Frangogiannis, Keith A. Youker, Roger D. Rossen, Marianne Gwechenberger, Merry H. Lindsey, Leonardo H. Mendoza, Lloyd H. Michael, Christie M. Ballantyne, C. Wayne Smith, Mark L. Entman

Research output: Contribution to journal › Article › peer-review

178 Scopus citations

Abstract

The intense inflammatory reaction following reperfusion of the infarcted myocardium has been implicated as a factor in extension of injury. However, this inflammatory reaction is also critical to tissue repair. The cellular responses that mediate these functions are orchestrated by sequential induction and/or release of cytokines resulting in a closely regulated cytokine cascade. This paper reviews research on these cytokine cascades, their cellular origin, and factors which control the cellular response to their presence. Factors examined include leukotaxis, phenotypic transition of leukocytes, adhesion molecule induction and the role of cytokines in tissue repair and scar formation.

Original language	English (US)
Pages (from-to)	2567-2576
Number of pages	10
Journal	Journal of Molecular and Cellular Cardiology
Volume	30
Issue number	12
DOIs	https://doi.org/10.1006/jmcc.1998.0829
State	Published - Dec 1998

Keywords

Cardiac tissue repair
Cytokines
Inflammation
Leukocytes
Reperfusion injury

ASJC Scopus subject areas

Molecular Biology
Cardiology and Cardiovascular Medicine

Access to Document

10.1006/jmcc.1998.0829

Cite this

@article{f201add6018145adb05ce2cd4f728083,

title = "Cytokines and the microcirculation in ischemia and reperfusion",

abstract = "The intense inflammatory reaction following reperfusion of the infarcted myocardium has been implicated as a factor in extension of injury. However, this inflammatory reaction is also critical to tissue repair. The cellular responses that mediate these functions are orchestrated by sequential induction and/or release of cytokines resulting in a closely regulated cytokine cascade. This paper reviews research on these cytokine cascades, their cellular origin, and factors which control the cellular response to their presence. Factors examined include leukotaxis, phenotypic transition of leukocytes, adhesion molecule induction and the role of cytokines in tissue repair and scar formation.",

keywords = "Cardiac tissue repair, Cytokines, Inflammation, Leukocytes, Reperfusion injury",

author = "Frangogiannis, {Nikolaos G.} and Youker, {Keith A.} and Rossen, {Roger D.} and Marianne Gwechenberger and Lindsey, {Merry H.} and Mendoza, {Leonardo H.} and Michael, {Lloyd H.} and Ballantyne, {Christie M.} and Smith, {C. Wayne} and Entman, {Mark L.}",

note = "Funding Information: This paper was presented at the XVI World Congress of the International Society for Heart Research as part of a symposium on the Microcirculation as a Foundation for Cardiovascular Disease which was organized with the help of an educational grant from the Servier Research Group. The research work was funded by HL42,550 from the National Institutes of Health, the American Heart Association and the DeBakey Heart Center. The authors wish to acknowledge the editorial assistance of Ms Sharon Malinowski and Ms Concepcion Mata.",

year = "1998",

month = dec,

doi = "10.1006/jmcc.1998.0829",

language = "English (US)",

volume = "30",

pages = "2567--2576",

journal = "Journal of Molecular and Cellular Cardiology",

issn = "0022-2828",

publisher = "Academic Press",

number = "12",

}

TY - JOUR

T1 - Cytokines and the microcirculation in ischemia and reperfusion

AU - Frangogiannis, Nikolaos G.

AU - Youker, Keith A.

AU - Rossen, Roger D.

AU - Gwechenberger, Marianne

AU - Lindsey, Merry H.

AU - Mendoza, Leonardo H.

AU - Michael, Lloyd H.

AU - Ballantyne, Christie M.

AU - Smith, C. Wayne

AU - Entman, Mark L.

N1 - Funding Information: This paper was presented at the XVI World Congress of the International Society for Heart Research as part of a symposium on the Microcirculation as a Foundation for Cardiovascular Disease which was organized with the help of an educational grant from the Servier Research Group. The research work was funded by HL42,550 from the National Institutes of Health, the American Heart Association and the DeBakey Heart Center. The authors wish to acknowledge the editorial assistance of Ms Sharon Malinowski and Ms Concepcion Mata.

PY - 1998/12

Y1 - 1998/12

N2 - The intense inflammatory reaction following reperfusion of the infarcted myocardium has been implicated as a factor in extension of injury. However, this inflammatory reaction is also critical to tissue repair. The cellular responses that mediate these functions are orchestrated by sequential induction and/or release of cytokines resulting in a closely regulated cytokine cascade. This paper reviews research on these cytokine cascades, their cellular origin, and factors which control the cellular response to their presence. Factors examined include leukotaxis, phenotypic transition of leukocytes, adhesion molecule induction and the role of cytokines in tissue repair and scar formation.

AB - The intense inflammatory reaction following reperfusion of the infarcted myocardium has been implicated as a factor in extension of injury. However, this inflammatory reaction is also critical to tissue repair. The cellular responses that mediate these functions are orchestrated by sequential induction and/or release of cytokines resulting in a closely regulated cytokine cascade. This paper reviews research on these cytokine cascades, their cellular origin, and factors which control the cellular response to their presence. Factors examined include leukotaxis, phenotypic transition of leukocytes, adhesion molecule induction and the role of cytokines in tissue repair and scar formation.

KW - Cardiac tissue repair

KW - Cytokines

KW - Inflammation

KW - Leukocytes

KW - Reperfusion injury

UR - http://www.scopus.com/inward/record.url?scp=13044267739&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=13044267739&partnerID=8YFLogxK

U2 - 10.1006/jmcc.1998.0829

DO - 10.1006/jmcc.1998.0829

M3 - Article

C2 - 9990529

AN - SCOPUS:13044267739

SN - 0022-2828

VL - 30

SP - 2567

EP - 2576

JO - Journal of Molecular and Cellular Cardiology

JF - Journal of Molecular and Cellular Cardiology

IS - 12

ER -

Cytokines and the microcirculation in ischemia and reperfusion

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this