Cystic Fibrosis Serum Pancreatic Amylase: Useful Discriminator of Exocrine Function

Baiba K. Gillard, Kenneth L. Cox, Paul A. Pollack, Mitchell E. Geffner

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

To develop a simple test for pancreatic exocrine function in patients with cystic fibrosis, we compared serum pancreatic amylase isoenzyme (P isoamylase) activity with the more complex standard tests of pancreatic function. Twenty-seven patients with cystic fibrosis, newborn to 46 years of age, were studied. All patients over 17 months old with evidence of pancreatic exocrine insuffiency, as manifested by abnormal duodenal secretions and/or abnormal 72-hour fecal fat absorption, had serum P isoamylase activity below the age-matched normal range; patients with adequate pancreatic function (aged 2 to 46 years) had P isoamylase activity in or above the normal range. Although both normal neonates and neonates with cystic fibrosis have very low levels of serum P isoamylase activity, in patients over 1 1/2 years of age serum P isoamylase activity may serve as a simple and useful discriminator of pancreatic exocrine function in patients with cystic fibrosis.

Original languageEnglish (US)
Pages (from-to)577-580
Number of pages4
JournalAmerican Journal of Diseases of Children
Volume138
Issue number6
DOIs
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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