Cyclosporine-Associated Central Nervous System Toxicity

To the Editor: The report by de Groen et al. (Oct. 1 issue)¹ describes the association of low serum cholesterol levels and cyclosporine-induced central nervous system toxicity after liver transplantation. We have recently examined a young woman with idiopathic hepatic fibrosis and low serum cholesterol who had central nervous system toxicity after cyclosporine therapy for kidney transplantation. A 25-year-old black woman had received a cadaveric kidney transplant for end-stage kidney disease secondary to systemic lupus erythematosus. She had also had biopsy-proved idiopathic hepatic fibrosis since childhood. After kidney transplantation, the patient was given 600 mg of cyclosporine daily. Cyclosporine levels.