Cyclic Nucleotides in Familial Mediterranean Fever

Zayfer Paykoc, Negüz Sümer, Atilla Ertan, Ayfer Akit

Research output: Contribution to journalLetterpeer-review

4 Scopus citations


To the Editor: We have studied plasma and urinary cyclic AMP in patients with familial Mediterranean fever and the ability of colchicine to abolish fever or diminish its severity in most patients in about three hours. In 41 patients with this disorder without renal disease, creatinine clearance (mean ± S.E.M.) was 125±6.5 liters per day (range, 100 to 153) between episodes of fever and 121±5.5 (range, 100 to 140) during fever. Ten healthy subjects and nine patients with acute bacterial peritonitis served as controls. Plasma and urinary cyclic nucleotides were measured by radioimmunoassay (Table 1). Plasma cyclic AMP, plasma cyclic.

Original languageEnglish (US)
Pages (from-to)1160-1161
Number of pages2
JournalNew England Journal of Medicine
Issue number20
StatePublished - May 17 1979

ASJC Scopus subject areas

  • Medicine(all)


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