Cyclic immune thrombocytopenia responsive to thrombopoietic growth factor therapy

Lawrence Rice; Janet L. Nichol; Robert McMillan; Lorin K. Roskos; Margaret Bacile

doi:10.1002/ajh.1181

Cyclic immune thrombocytopenia responsive to thrombopoietic growth factor therapy

Lawrence Rice, Janet L. Nichol, Robert McMillan, Lorin K. Roskos, Margaret Bacile

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49 Scopus citations

Abstract

We report a patient with cyclic thrombocytopenia and antiplatelet antibodies, a variant of chronic immune thrombocytopenic purpura (ITP), with a several year history of periodic fluctuation of the platelet count, megakaryocytic hyperplasia and high-titer anti-GPIb-specific antiplatelet antibodies. The patient was resistant to multiple forms of therapy but has responded to the thrombopoietic growth factor, pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF). This case suggests that some patients with classic ITP may respond to thrombopoietic growth factors.

Original language	English (US)
Pages (from-to)	210-214
Number of pages	5
Journal	American Journal of Hematology
Volume	68
Issue number	3
DOIs	https://doi.org/10.1002/ajh.1181
State	Published - 2001

Keywords

Antiplatelet antibody
Cyclic thrombocytopenia
ITP
Thrombopoietin

ASJC Scopus subject areas

Hematology

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10.1002/ajh.1181

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abstract = "We report a patient with cyclic thrombocytopenia and antiplatelet antibodies, a variant of chronic immune thrombocytopenic purpura (ITP), with a several year history of periodic fluctuation of the platelet count, megakaryocytic hyperplasia and high-titer anti-GPIb-specific antiplatelet antibodies. The patient was resistant to multiple forms of therapy but has responded to the thrombopoietic growth factor, pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF). This case suggests that some patients with classic ITP may respond to thrombopoietic growth factors.",

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AB - We report a patient with cyclic thrombocytopenia and antiplatelet antibodies, a variant of chronic immune thrombocytopenic purpura (ITP), with a several year history of periodic fluctuation of the platelet count, megakaryocytic hyperplasia and high-titer anti-GPIb-specific antiplatelet antibodies. The patient was resistant to multiple forms of therapy but has responded to the thrombopoietic growth factor, pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF). This case suggests that some patients with classic ITP may respond to thrombopoietic growth factors.

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KW - Thrombopoietin

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Cyclic immune thrombocytopenia responsive to thrombopoietic growth factor therapy

Abstract

Keywords

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