Cyanonitrosylmetallates as potential NO-donors

J Oszajca; G Stochel; E Wasielewska; Z Stasicka; R J Gryglewski; A Jakubowski; Katarzyna A. Cieslik

doi:10.1016/s0162-0134(97)10032-0

Cyanonitrosylmetallates as potential NO-donors

J Oszajca, G Stochel, E Wasielewska, Z Stasicka, R J Gryglewski, A Jakubowski, Katarzyna A. Cieslik

Houston Methodist

Research output: Contribution to journal › Article › peer-review

Abstract

The [M(CN)xNOy]n- complexes (where M = Cr(I), Mn(I), Mn(II), Fe(I), Fe(II), Fe(III)) were studied as potential NO-donors using both pharmacological and theoretical semi-empirical methods. Only iron complexes appeared to be pharmacologically active. The quantum chemical calculations indicated that these complexes have the highest predisposition to undergo a nucleophilic attack followed by the NO+ release. The results allowed us to interpret the metabolism of the [M(CN)xNOy]n- complexes in terms of the NO(+)-donation.

Original language	English (US)
Pages (from-to)	121-7
Number of pages	7
Journal	Journal of Inorganic Biochemistry
Volume	69
Issue number	1-2
DOIs	https://doi.org/10.1016/s0162-0134(97)10032-0
State	Published - Feb 1 1998

Keywords

Adult
Animals
Female
Humans
Hydrogen-Ion Concentration
Male
Middle Aged
Models, Chemical
Nitric Oxide/metabolism
Nitroprusside/pharmacology
Organometallic Compounds/pharmacology
Rabbits
Temperature
Vasodilator Agents/pharmacology

Access to Document

10.1016/s0162-0134(97)10032-0

Cite this

@article{a2b8becce36049328edae517029b2ff3,

title = "Cyanonitrosylmetallates as potential NO-donors",

abstract = "The [M(CN)xNOy]n- complexes (where M = Cr(I), Mn(I), Mn(II), Fe(I), Fe(II), Fe(III)) were studied as potential NO-donors using both pharmacological and theoretical semi-empirical methods. Only iron complexes appeared to be pharmacologically active. The quantum chemical calculations indicated that these complexes have the highest predisposition to undergo a nucleophilic attack followed by the NO+ release. The results allowed us to interpret the metabolism of the [M(CN)xNOy]n- complexes in terms of the NO(+)-donation.",

keywords = "Adult, Animals, Female, Humans, Hydrogen-Ion Concentration, Male, Middle Aged, Models, Chemical, Nitric Oxide/metabolism, Nitroprusside/pharmacology, Organometallic Compounds/pharmacology, Rabbits, Temperature, Vasodilator Agents/pharmacology",

author = "J Oszajca and G Stochel and E Wasielewska and Z Stasicka and Gryglewski, \{R J\} and A Jakubowski and Cieslik, \{Katarzyna A.\}",

year = "1998",

month = feb,

day = "1",

doi = "10.1016/s0162-0134(97)10032-0",

language = "English (US)",

volume = "69",

pages = "121--7",

journal = "Journal of Inorganic Biochemistry",

issn = "0162-0134",

publisher = "Elsevier",

number = "1-2",

}

TY - JOUR

T1 - Cyanonitrosylmetallates as potential NO-donors

AU - Oszajca, J

AU - Stochel, G

AU - Wasielewska, E

AU - Stasicka, Z

AU - Gryglewski, R J

AU - Jakubowski, A

AU - Cieslik, Katarzyna A.

PY - 1998/2/1

Y1 - 1998/2/1

N2 - The [M(CN)xNOy]n- complexes (where M = Cr(I), Mn(I), Mn(II), Fe(I), Fe(II), Fe(III)) were studied as potential NO-donors using both pharmacological and theoretical semi-empirical methods. Only iron complexes appeared to be pharmacologically active. The quantum chemical calculations indicated that these complexes have the highest predisposition to undergo a nucleophilic attack followed by the NO+ release. The results allowed us to interpret the metabolism of the [M(CN)xNOy]n- complexes in terms of the NO(+)-donation.

AB - The [M(CN)xNOy]n- complexes (where M = Cr(I), Mn(I), Mn(II), Fe(I), Fe(II), Fe(III)) were studied as potential NO-donors using both pharmacological and theoretical semi-empirical methods. Only iron complexes appeared to be pharmacologically active. The quantum chemical calculations indicated that these complexes have the highest predisposition to undergo a nucleophilic attack followed by the NO+ release. The results allowed us to interpret the metabolism of the [M(CN)xNOy]n- complexes in terms of the NO(+)-donation.

KW - Adult

KW - Animals

KW - Female

KW - Humans

KW - Hydrogen-Ion Concentration

KW - Male

KW - Middle Aged

KW - Models, Chemical

KW - Nitric Oxide/metabolism

KW - Nitroprusside/pharmacology

KW - Organometallic Compounds/pharmacology

KW - Rabbits

KW - Temperature

KW - Vasodilator Agents/pharmacology

U2 - 10.1016/s0162-0134(97)10032-0

DO - 10.1016/s0162-0134(97)10032-0

M3 - Article

C2 - 9606942

SN - 0162-0134

VL - 69

SP - 121

EP - 127

JO - Journal of Inorganic Biochemistry

JF - Journal of Inorganic Biochemistry

IS - 1-2

ER -

Cyanonitrosylmetallates as potential NO-donors

Abstract

Keywords

Access to Document

Fingerprint

Cite this