Cu2+-labeled dansyl compounds as fluorescent and PET probes for imaging apoptosis

Junyan Han, Xukui Wang, Meixiang Max Yu

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Compound DNSTT–Cu2+, a novel chelate of Cu2+with DOTA conjugated to a fluorescent dansyl fragment, is developed for imaging cell apoptosis. Apoptotic U-87MG cells could be selectively visualized by the fluorescence of DNSTT–Cu2+from cytoplasm of cells, confirmed by the fluorescence of apoptosis cells co-labeled with Alexa Fluor 568-labeled annexin V, a conventional probe for selectively labeling membranes of apoptosis cells. A radioactive64Cu2+analog, DNSTT–64Cu2+, was easily synthesized, providing a potential PET probe for imaging apoptosis in vivo.

Original languageEnglish (US)
Pages (from-to)5594-5596
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume26
Issue number22
DOIs
StatePublished - Jan 1 2016

Keywords

  • Annexin V
  • Apoptosis imaging
  • Cu
  • Dansyl compound
  • PET

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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