TY - JOUR
T1 - Current status of ischemia and reperfusion injury in the liver
AU - Farmer, Douglas G.
AU - Amersi, Farin
AU - Kupiec-Weglinski, Jerzy
AU - Busuttil, Ronald W.
PY - 2000
Y1 - 2000
N2 - Ischemia/reperfusion (I/R) injury is a major obstacle affecting graft function after liver transplantation. The cause of this injury is multifactorial. A detailed understanding of the mechanisms involved in I/R injury is important for the design of effective therapeutic agents to ameliorate this process and improve outcome after transplantation. Increasing experimental evidence has suggested that Kupffer cells, neutrophils, endothelial cells, and reactive oxygen species can contribute significantly to the pathogenesis of I/R injury. This review serves as an overview of the role of these important mediators in I/R injury. A general introduction of the histopathological and microcirculatory changes occurring in response to I/R is presented. Therapeutic interventions that have been developed to reduce hepatic I/R injury, which target various steps in this cascade of events, is also provided.
AB - Ischemia/reperfusion (I/R) injury is a major obstacle affecting graft function after liver transplantation. The cause of this injury is multifactorial. A detailed understanding of the mechanisms involved in I/R injury is important for the design of effective therapeutic agents to ameliorate this process and improve outcome after transplantation. Increasing experimental evidence has suggested that Kupffer cells, neutrophils, endothelial cells, and reactive oxygen species can contribute significantly to the pathogenesis of I/R injury. This review serves as an overview of the role of these important mediators in I/R injury. A general introduction of the histopathological and microcirculatory changes occurring in response to I/R is presented. Therapeutic interventions that have been developed to reduce hepatic I/R injury, which target various steps in this cascade of events, is also provided.
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U2 - 10.1053/tr.2000.4651
DO - 10.1053/tr.2000.4651
M3 - Article
AN - SCOPUS:0001443254
VL - 14
SP - 106
EP - 126
JO - Transplantation Reviews
JF - Transplantation Reviews
SN - 0955-470X
IS - 2
ER -