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Current Management of Serious Infections due to Vancomycin-resistant Enterococci

Sara I. Gomez-Villegas, William R. Miller, Cesar A. Arias

Research output: Contribution to journalArticlepeer-review

Abstract

Vancomycin-resistant enterococci (VRE) are major health care-associated pathogens and significantly contribute to patient morbidity and mortality, particularly in immunocompromised and critically ill patients. The clinical management of VRE infections is challenging due to limited therapeutic options and the paucity of high quality clinical data to guide management. Delays in initiating appropriate therapy has proven to have significant impact in VRE-associated bloodstream infections. This review summarizes the current evidence on treatment strategies for serious VRE infections, incluiding bacteremia and endocarditis, as well as emerging treatment strategies for these recalcitrant organisms.

Original languageEnglish (US)
Pages (from-to)183-203
Number of pages21
JournalInfectious Disease Clinics of North America
Volume40
Issue number1
DOIs
StatePublished - Mar 2026

Keywords

  • Bacteremia
  • Daptomycin
  • Endocarditis
  • Enterococci
  • Health care-acquired infection
  • Linezolid
  • Multidrug-resistant microorganisms
  • VRE (vancomycin-resistant enterococci)
  • Humans
  • Endocarditis, Bacterial/drug therapy
  • Cross Infection/drug therapy
  • Vancomycin/therapeutic use
  • Bacteremia/drug therapy
  • Gram-Positive Bacterial Infections/drug therapy
  • Anti-Bacterial Agents/therapeutic use
  • Vancomycin-Resistant Enterococci/drug effects

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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