Current experimental therapy for Alzheimer's disease

Sheng Chen, Xiao Jie Zhang, Liang Li, Wei Dong Le

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

In the past decade, enormous efforts have been devoted to understand the genetics and molecular pathogenesis of Alzheimer's disease (AD), which has been transferred into extensive experimental approaches aimed at reversing disease progression. The trend in future AD therapy has been shifted from traditional anti-acetylcholinesterase treatment to multiple mechanisms-based therapy targeting amyloid plaques formation and amyloid peptides (Aβ)-mediated cytotoxicity, and neurofibrillary tangles generation. This review will cover current experimental studies with the focus on secretases-based drug development, immunotherapy, and anti-neurofibrillary tangles intervention. The outcome of these on-going studies may provide high hope that AD can be cured in the future.

Original languageEnglish (US)
Pages (from-to)127-134
Number of pages8
JournalCurrent Neuropharmacology
Volume5
Issue number2
DOIs
StatePublished - Jun 2007

Keywords

  • Alzheimer's disease
  • Amyloid plaque
  • Experimental approach
  • Gene therapy
  • Immunotherapy
  • Neurofibrillary tangles
  • Secretase
  • Small interfering molecule

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Pharmacology
  • Psychiatry and Mental health

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