Abstract
An increasing amount of evidence points at important roles for estrogen receptors in prostate carcinogenesis and progression. Of the two estrogen receptors, estrogen receptor β is the most prominent within the prostate gland. Although there is much yet to be known, the findings from the discovery of the receptor in 1996 until now point at a role of the receptor in maintaining differentiation and reducing cellular proliferation in the prostate. Moreover, estrogen receptor β is the main target for phytoestrogens, perhaps at least partially explaining the difference in incidence of prostate cancer in the Western world compared to Asia where the intake of soy-based, phytoestrogen-rich food is higher. The tumor suppressive capability of estrogen receptor β makes it a promising drug target for the treatment and prevention of prostate cancer. This review will focus on different aspects of estrogen receptor signaling and prostate cancer.
Original language | English (US) |
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Pages (from-to) | 1262-1266 |
Number of pages | 5 |
Journal | Steroids |
Volume | 77 |
Issue number | 12 |
DOIs | |
State | Published - Oct 2012 |
Keywords
- Estrogen receptor beta
- Phytoestrogens
- Prostate cancer
- Prostate cancer prevention
- Targeted therapies
ASJC Scopus subject areas
- Biochemistry
- Clinical Biochemistry
- Endocrinology
- Molecular Biology
- Organic Chemistry
- Pharmacology