Current concepts and significance of estrogen receptor β in prostate cancer

Johan Hartman, Anders Ström, Jan Åke Gustafsson

Research output: Contribution to journalReview articlepeer-review

49 Scopus citations

Abstract

An increasing amount of evidence points at important roles for estrogen receptors in prostate carcinogenesis and progression. Of the two estrogen receptors, estrogen receptor β is the most prominent within the prostate gland. Although there is much yet to be known, the findings from the discovery of the receptor in 1996 until now point at a role of the receptor in maintaining differentiation and reducing cellular proliferation in the prostate. Moreover, estrogen receptor β is the main target for phytoestrogens, perhaps at least partially explaining the difference in incidence of prostate cancer in the Western world compared to Asia where the intake of soy-based, phytoestrogen-rich food is higher. The tumor suppressive capability of estrogen receptor β makes it a promising drug target for the treatment and prevention of prostate cancer. This review will focus on different aspects of estrogen receptor signaling and prostate cancer.

Original languageEnglish (US)
Pages (from-to)1262-1266
Number of pages5
JournalSteroids
Volume77
Issue number12
DOIs
StatePublished - Oct 2012

Keywords

  • Estrogen receptor beta
  • Phytoestrogens
  • Prostate cancer
  • Prostate cancer prevention
  • Targeted therapies

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Molecular Biology
  • Organic Chemistry
  • Pharmacology

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