Current concepts and significance of estrogen receptor β in prostate cancer

Johan Hartman, Anders Ström, Jan-Ake Gustafsson

Research output: Contribution to journalReview article

48 Scopus citations

Abstract

An increasing amount of evidence points at important roles for estrogen receptors in prostate carcinogenesis and progression. Of the two estrogen receptors, estrogen receptor β is the most prominent within the prostate gland. Although there is much yet to be known, the findings from the discovery of the receptor in 1996 until now point at a role of the receptor in maintaining differentiation and reducing cellular proliferation in the prostate. Moreover, estrogen receptor β is the main target for phytoestrogens, perhaps at least partially explaining the difference in incidence of prostate cancer in the Western world compared to Asia where the intake of soy-based, phytoestrogen-rich food is higher. The tumor suppressive capability of estrogen receptor β makes it a promising drug target for the treatment and prevention of prostate cancer. This review will focus on different aspects of estrogen receptor signaling and prostate cancer.

Original languageEnglish (US)
Pages (from-to)1262-1266
Number of pages5
JournalSteroids
Volume77
Issue number12
DOIs
StatePublished - Oct 1 2012

Keywords

  • Estrogen receptor beta
  • Phytoestrogens
  • Prostate cancer
  • Prostate cancer prevention
  • Targeted therapies

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Molecular Biology
  • Organic Chemistry
  • Pharmacology

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