Curing hepatitis C in liver transplant recipients is associated with changes in immunosuppressant use

Sammy Saab, Justin Rheem, Melissa Jimenez, Sherona Bau, Gina Choi, Francisco Durazo, Mohammed El Kabany, Steven Han, Alexander Farid, Naadir Jamal, Jonathan Grotts, David Elashoff, Ronald W. Busuttil

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Background and Aims: All-oral interferon-free antivirals are highly effective in treating recurrent hepatitis C (HCV) infection in liver transplant (LT) recipients. The aim of the study was to assess immunosuppression needs after achieving a sustained viral response (SVR). Methods: We compared im-munosuppression needs before and after achieving a SVR in adult LT recipients treated for recurrent HCV infection with all-oral direct acting agents. Results: We identified 52 liver LT treated recipients who achieved a SVR. The median (25th and 75th percentile interquartile range [IQR]) age was 62 years (57.75, 65). Most recipients received tacrolimus (TAC) for their immunosuppressant regimen. After achieving SVR, there was no statistically significant difference in daily dose of TAC unadjusted per weight (p > 0.05). However, there was a statistically significant decrease in daily dose of TAC adjusted per weight, serum levels of TAC, and the product of glomerular filtration rate and TAC. No statistically significant differences in cyclosporine unadjusted/adjusted per weight daily dose or serum levels were noted. Conclusions: Immunosuppression needs were increased for those patients treated with TAC but not cyclosporine. LT recipients prescribed TAC require close monitoring after treatment completion to avoid potential risk of acute rejection.

Original languageEnglish (US)
Pages (from-to)32-38
Number of pages7
JournalJournal of Clinical and Translational Hepatology
Issue number1
StatePublished - 2016


  • Direct acting agents
  • Hepatitis C
  • Immunosuppressant
  • Liver transplantation

ASJC Scopus subject areas

  • Gastroenterology


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