Cubosomes and hexosomes as versatile platforms for drug delivery

Intan D.M. Azmi, Seyed Moghimi, Anan Yaghmur

Research output: Contribution to journalReview articlepeer-review

112 Scopus citations


Nonlamellar liquid crystalline phases are attractive platforms for drug solubilization and targeted delivery. The attractiveness of this formulation principle is linked to the nanostructural versatility, compatiblity, digestiblity and bioadhesive properties of their lipid constituents, and the capability of solubilizing and sustaining the release of amphiphilic, hydrophobic and hydrophilic drugs. Nonlamellar liquid crystalline phases offer two distinct promising strategies in the development of drug delivery systems. These comprise formation of ISAsomes (internally self-assembled 'somes' or particles) such as cubosomes and hexosomes, and in situ formation of parenteral dosage forms with tunable nanostructures at the site of administration. This review outlines the unique features of cubosomes and hexosomes and their potential utilization as promising platforms for drug delivery.

Original languageEnglish (US)
Pages (from-to)1347-1364
Number of pages18
JournalTherapeutic Delivery
Issue number12
StatePublished - Dec 1 2015

ASJC Scopus subject areas

  • Pharmaceutical Science


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