CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells

Janine Morales, Bernhard Homey, Alain P. Vicari, Susan Hudak, Elizabeth Oldham, Joseph Hedrick, Rocio Orozco, Neal G. Copeland, Nancy A. Jenkins, Leslie M. McEvoy, Albert Zlotnik

Research output: Contribution to journalArticle

418 Scopus citations

Abstract

In contrast to naive lymphocytes, memory/effector lymphocytes can access nonlymphoid effector sites and display restricted, often tissue-selective, migration behavior. The cutaneous lymphocyte-associated antigen (CLA) defines a subset of circulating memory T cells that selectively localize in cutaneous sites mediated in part by the interaction of CLA with its vascular ligand E- selectin. Here, we report the identification and characterization of a CC chemokine, cutaneous T cell-attracting chemokine (CTACK). Both human and mouse CTACK are detected only in skin by Southern and Northern blot analyses. Specifically, CTACK message is found in the mouse epidermis and in human keratinocytes, and anti-CTACK mAbs predominantly stain the epithelium. Finally, CTACK selectively attracts CLA+ memory T cells. Taken together, these results suggest an important role for CTACK in recruitment of CLA+ T cells to cutaneous sites. CTACK is predominantly expressed in the skin and selectively attracts a tissue-specific subpopulation of memory lymphocytes.

Original languageEnglish (US)
Pages (from-to)14470-14475
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume96
Issue number25
DOIs
StatePublished - Dec 7 1999

ASJC Scopus subject areas

  • General

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