Crystallization of citrate-stabilized amorphous calcium phosphate to nanocrystalline apatite: A surface-mediated transformation

Konstantinos Chatzipanagis; Michele Iafisco; Teresa Roncal-Herrero; Matthew Bilton; Anna Tampieri; Roland Kröger; José Manuel Delgado-López

doi:10.1039/c6ce00521g

Crystallization of citrate-stabilized amorphous calcium phosphate to nanocrystalline apatite: A surface-mediated transformation

Konstantinos Chatzipanagis, Michele Iafisco, Teresa Roncal-Herrero, Matthew Bilton, Anna Tampieri, Roland Kröger, José Manuel Delgado-López

Houston Methodist

Research output: Contribution to journal › Article › peer-review

77 Scopus citations

Abstract

This work explores the mechanisms underlying the crystallization of citrate-functionalized amorphous calcium phosphate (cit-ACP) in two relevant media, combining in situ and ex situ characterization techniques. Results demonstrate that citrate desorption from cit-ACP triggers the surface-mediated transformation to nanocrystalline apatite (Ap). Our findings shed light on the key role of citrate, an important component of bone organic matrix, and the medium composition in controlling the rate of transformation and the morphology of the resulting Ap phase.

Original language	English (US)
Pages (from-to)	3170-3173
Number of pages	4
Journal	CrystEngComm
Volume	18
Issue number	18
DOIs	https://doi.org/10.1039/c6ce00521g
State	Published - 2016

ASJC Scopus subject areas

General Chemistry
General Materials Science
Condensed Matter Physics

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@article{b58c3e0c65304481bf867cd48588589f,

title = "Crystallization of citrate-stabilized amorphous calcium phosphate to nanocrystalline apatite: A surface-mediated transformation",

abstract = "This work explores the mechanisms underlying the crystallization of citrate-functionalized amorphous calcium phosphate (cit-ACP) in two relevant media, combining in situ and ex situ characterization techniques. Results demonstrate that citrate desorption from cit-ACP triggers the surface-mediated transformation to nanocrystalline apatite (Ap). Our findings shed light on the key role of citrate, an important component of bone organic matrix, and the medium composition in controlling the rate of transformation and the morphology of the resulting Ap phase.",

author = "Konstantinos Chatzipanagis and Michele Iafisco and Teresa Roncal-Herrero and Matthew Bilton and Anna Tampieri and Roland Kr{\"o}ger and Delgado-L{\'o}pez, \{Jos{\'e} Manuel\}",

note = "Funding Information: This work has been carried out in the framework of the projects SMILEY (FP7-NMP-2012-SMALL-6-310637), BioBone (Andaluca Talent Hub, co-funded by Junta de Andaluca and EU-FP7 within the Marie-Curie Actions), the UK Engineering and Physical Sciences Research Council (EPSRC) (Grant No. EP/I001514/1), funding the Material Interface with Biology (MIB) consortium, and the short-term mobility program (STM 2015) from the National Research Council of Italy (CNR) for J. M. D.-L. We would like also to thank York JEOL Nanocentre for the use of their facilities. Publisher Copyright: {\textcopyright} 2016 The Royal Society of Chemistry.",

year = "2016",

doi = "10.1039/c6ce00521g",

language = "English (US)",

volume = "18",

pages = "3170--3173",

journal = "CrystEngComm",

issn = "1466-8033",

publisher = "Royal Society of Chemistry",

number = "18",

}

TY - JOUR

T1 - Crystallization of citrate-stabilized amorphous calcium phosphate to nanocrystalline apatite

T2 - A surface-mediated transformation

AU - Chatzipanagis, Konstantinos

AU - Iafisco, Michele

AU - Roncal-Herrero, Teresa

AU - Bilton, Matthew

AU - Tampieri, Anna

AU - Kröger, Roland

AU - Delgado-López, José Manuel

N1 - Funding Information: This work has been carried out in the framework of the projects SMILEY (FP7-NMP-2012-SMALL-6-310637), BioBone (Andaluca Talent Hub, co-funded by Junta de Andaluca and EU-FP7 within the Marie-Curie Actions), the UK Engineering and Physical Sciences Research Council (EPSRC) (Grant No. EP/I001514/1), funding the Material Interface with Biology (MIB) consortium, and the short-term mobility program (STM 2015) from the National Research Council of Italy (CNR) for J. M. D.-L. We would like also to thank York JEOL Nanocentre for the use of their facilities. Publisher Copyright: © 2016 The Royal Society of Chemistry.

PY - 2016

Y1 - 2016

N2 - This work explores the mechanisms underlying the crystallization of citrate-functionalized amorphous calcium phosphate (cit-ACP) in two relevant media, combining in situ and ex situ characterization techniques. Results demonstrate that citrate desorption from cit-ACP triggers the surface-mediated transformation to nanocrystalline apatite (Ap). Our findings shed light on the key role of citrate, an important component of bone organic matrix, and the medium composition in controlling the rate of transformation and the morphology of the resulting Ap phase.

AB - This work explores the mechanisms underlying the crystallization of citrate-functionalized amorphous calcium phosphate (cit-ACP) in two relevant media, combining in situ and ex situ characterization techniques. Results demonstrate that citrate desorption from cit-ACP triggers the surface-mediated transformation to nanocrystalline apatite (Ap). Our findings shed light on the key role of citrate, an important component of bone organic matrix, and the medium composition in controlling the rate of transformation and the morphology of the resulting Ap phase.

UR - https://www.scopus.com/pages/publications/84966899788

UR - https://www.scopus.com/inward/citedby.url?scp=84966899788&partnerID=8YFLogxK

U2 - 10.1039/c6ce00521g

DO - 10.1039/c6ce00521g

M3 - Article

AN - SCOPUS:84966899788

SN - 1466-8033

VL - 18

SP - 3170

EP - 3173

JO - CrystEngComm

JF - CrystEngComm

IS - 18

ER -

Crystallization of citrate-stabilized amorphous calcium phosphate to nanocrystalline apatite: A surface-mediated transformation

Abstract

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