@article{b58c3e0c65304481bf867cd48588589f,
title = "Crystallization of citrate-stabilized amorphous calcium phosphate to nanocrystalline apatite: A surface-mediated transformation",
abstract = "This work explores the mechanisms underlying the crystallization of citrate-functionalized amorphous calcium phosphate (cit-ACP) in two relevant media, combining in situ and ex situ characterization techniques. Results demonstrate that citrate desorption from cit-ACP triggers the surface-mediated transformation to nanocrystalline apatite (Ap). Our findings shed light on the key role of citrate, an important component of bone organic matrix, and the medium composition in controlling the rate of transformation and the morphology of the resulting Ap phase.",
author = "Konstantinos Chatzipanagis and Michele Iafisco and Teresa Roncal-Herrero and Matthew Bilton and Anna Tampieri and Roland Kr{\"o}ger and Delgado-L{\'o}pez, \{Jos{\'e} Manuel\}",
note = "Funding Information: This work has been carried out in the framework of the projects SMILEY (FP7-NMP-2012-SMALL-6-310637), BioBone (Andaluca Talent Hub, co-funded by Junta de Andaluca and EU-FP7 within the Marie-Curie Actions), the UK Engineering and Physical Sciences Research Council (EPSRC) (Grant No. EP/I001514/1), funding the Material Interface with Biology (MIB) consortium, and the short-term mobility program (STM 2015) from the National Research Council of Italy (CNR) for J. M. D.-L. We would like also to thank York JEOL Nanocentre for the use of their facilities. Publisher Copyright: {\textcopyright} 2016 The Royal Society of Chemistry.",
year = "2016",
doi = "10.1039/c6ce00521g",
language = "English (US)",
volume = "18",
pages = "3170--3173",
journal = "CrystEngComm",
issn = "1466-8033",
publisher = "Royal Society of Chemistry",
number = "18",
}