TY - JOUR
T1 - Crystallization of citrate-stabilized amorphous calcium phosphate to nanocrystalline apatite
T2 - A surface-mediated transformation
AU - Chatzipanagis, Konstantinos
AU - Iafisco, Michele
AU - Roncal-Herrero, Teresa
AU - Bilton, Matthew
AU - Tampieri, Anna
AU - Kröger, Roland
AU - Delgado-López, José Manuel
N1 - Funding Information:
This work has been carried out in the framework of the projects SMILEY (FP7-NMP-2012-SMALL-6-310637), BioBone (Andaluca Talent Hub, co-funded by Junta de Andaluca and EU-FP7 within the Marie-Curie Actions), the UK Engineering and Physical Sciences Research Council (EPSRC) (Grant No. EP/I001514/1), funding the Material Interface with Biology (MIB) consortium, and the short-term mobility program (STM 2015) from the National Research Council of Italy (CNR) for J. M. D.-L. We would like also to thank York JEOL Nanocentre for the use of their facilities.
Publisher Copyright:
© 2016 The Royal Society of Chemistry.
PY - 2016
Y1 - 2016
N2 - This work explores the mechanisms underlying the crystallization of citrate-functionalized amorphous calcium phosphate (cit-ACP) in two relevant media, combining in situ and ex situ characterization techniques. Results demonstrate that citrate desorption from cit-ACP triggers the surface-mediated transformation to nanocrystalline apatite (Ap). Our findings shed light on the key role of citrate, an important component of bone organic matrix, and the medium composition in controlling the rate of transformation and the morphology of the resulting Ap phase.
AB - This work explores the mechanisms underlying the crystallization of citrate-functionalized amorphous calcium phosphate (cit-ACP) in two relevant media, combining in situ and ex situ characterization techniques. Results demonstrate that citrate desorption from cit-ACP triggers the surface-mediated transformation to nanocrystalline apatite (Ap). Our findings shed light on the key role of citrate, an important component of bone organic matrix, and the medium composition in controlling the rate of transformation and the morphology of the resulting Ap phase.
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U2 - 10.1039/c6ce00521g
DO - 10.1039/c6ce00521g
M3 - Article
AN - SCOPUS:84966899788
SN - 1466-8033
VL - 18
SP - 3170
EP - 3173
JO - CrystEngComm
JF - CrystEngComm
IS - 18
ER -