TY - JOUR
T1 - Cryptococcal meningoencephalitis in patients with mantle cell lymphoma on ibrutinib
AU - Sun, Kai
AU - Kasparian, Saro
AU - Iyer, Swaminathan
AU - Pingali, Sai Ravi
PY - 2018/5/17
Y1 - 2018/5/17
N2 - Ibrutinib, a Bruton's tyrosine kinase inhibitor, has been increasingly widely used in relapsed and refractory mantle cell lymphoma (MCL) and chronic lymphocytic leukaemia [1, 2]. With its use becoming more common, there have been emerging case reports of opportunistic infections like cryptococcal infections [3-8]. These infections in patients receiving ibrutinib were mostly reported in patients with chronic lymphocytic leukaemia, who have poor immune reconstitution. Here, we report two cases of cryptococcal meningoencephalitis in patients with MCL on ibrutinib.
AB - Ibrutinib, a Bruton's tyrosine kinase inhibitor, has been increasingly widely used in relapsed and refractory mantle cell lymphoma (MCL) and chronic lymphocytic leukaemia [1, 2]. With its use becoming more common, there have been emerging case reports of opportunistic infections like cryptococcal infections [3-8]. These infections in patients receiving ibrutinib were mostly reported in patients with chronic lymphocytic leukaemia, who have poor immune reconstitution. Here, we report two cases of cryptococcal meningoencephalitis in patients with MCL on ibrutinib.
KW - Cryptococcal meningoencephalitis
KW - Ibrutinib
KW - Mental cell lymphoma
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U2 - 10.3332/ecancer.2018.836
DO - 10.3332/ecancer.2018.836
M3 - Article
AN - SCOPUS:85047266201
VL - 12
JO - ecancermedicalscience
JF - ecancermedicalscience
SN - 1754-6605
M1 - 836
ER -