Cryopreserved Cadaveric Arterial Allograft for Arterial Reconstruction in Patients with Prosthetic Infection

Anne Lejay, Charline Delay, Elie Girsowicz, Bettina Chenesseau, Emilie Bonnin, Mohamed Zied Ghariani, Fabien Thaveau, Yannick Georg, Bernard Geny, Nabil Chakfe

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Objective The aim of this study was to report outcomes of cryopreserved arterial allografts used as a vascular substitute in the setting of prosthetic material infection. Methods A retrospective analysis of prospectively collected data was conducted including all consecutive interventions performed with cryopreserved arterial allografts used for vascular reconstruction in the setting of prosthetic material infection between January 2005 and December 2014. Five year outcomes included allograft related re-interventions, survival, primary patency, and limb salvage rates. Results Fifty-three procedures were performed using cryopreserved allografts for vascular prosthetic infection: 25 procedures (47%) were performed at aorto-iliac level (Group 1) and 28 procedures (53%) at peripheral level (Group 2). The mean follow-up was 52 months. Five year allograft related re-intervention was 55% in Group 1 (6 allograft ruptures and 5 allograft aneurysm degenerations) and 33% in Group 2 (2 allograft ruptures and 7 allograft aneurysm degenerations). Five year survival was 40% and 68%, primary patency was 89% and 59% and limb salvage was 100% and 89% for Group 1 and 2 respectively. Conclusion Use of cryopreserved arterial allografts provides acceptable results but is tempered by suboptimal 5 year outcomes with high re-intervention rates.

Original languageEnglish (US)
Pages (from-to)636-644
Number of pages9
JournalEuropean Journal of Vascular and Endovascular Surgery
Volume54
Issue number5
DOIs
StatePublished - Nov 2017

Keywords

  • Aorto-enteric fistula
  • Cryopreserved allografts
  • Infection

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine

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