Cross-reactive antibodies in type b and nontypeable hemophilus influenzae-induced experimental otitis media

Tatsuji Yamaguchi, Thomas F. Demaria, David J. Lim

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Cross-reactive antibodies directed against type b (TBHI) or serologically nontypeable (NTHI) strains of Hemophilus influenzae were investigated in experimental otitis media. Cross-reactive antibody to TBHI was demonstrated in sera and middle ears from chinchillas infected with an NTHI, and cross-reactive antibody to NTHI developed in sera and middle ears of chinchillas challenged with TBHI. The absorption test data presented indicate that the sera and middle ear effusions from chinchillas challenged with either TBHI or NTHI had not only specific antibody activity to the challenged strain but also antibody activities against the probable common cell antigens of H influenzae. These data indicate that it may be possible to develop a polyvalent vaccine effective against the various and divergent strains of H influenzae, including the serologically nontypeable isolates.

Original languageEnglish (US)
Pages (from-to)325-329
Number of pages5
JournalAnnals of Otology, Rhinology & Laryngology
Volume96
Issue number3
DOIs
StatePublished - May 1987

Keywords

  • Hemophilus influenzae
  • cross-reactivity
  • enzyme-linked immunosorbent assay
  • experimental otitis media with effusion

ASJC Scopus subject areas

  • Otorhinolaryngology

Fingerprint Dive into the research topics of 'Cross-reactive antibodies in type b and nontypeable hemophilus influenzae-induced experimental otitis media'. Together they form a unique fingerprint.

Cite this