Cross-immune tolerance: Conception and its potential significance on transplantation tolerance

Yong Zhao, Xianchang Li

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


The diversity of alloreactive T cells in graft rejection and the presence of extensive crossreactivity among alloreactive T cells indicate that the induction of transplantation tolerance may fundamentally alter the size of host T-cell repertoire involved in protective immunity and immune surveillance, especially those that are crossreactive to conventional antigens. We herein highlight the crossreactive nature of alloreactive T cells and the potential risks of altered T-cell repertoire associated with the induction of transplantation tolerance. The possibility that T-cell tolerance to one set of antigens results in their tolerance to other unrelated antigens due to T-cell crossreactivity and/or heterogeneity is defined as cross-immune tolerance. The definition and significance of this concept were discussed in details.

Original languageEnglish (US)
Pages (from-to)20-25
Number of pages6
JournalCellular and Molecular Immunology
Issue number1
StatePublished - Jan 2010


  • Crossreactivity
  • T-cell repertoire
  • Tolerance
  • Transplantation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology


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