TY - JOUR
T1 - Cross-domain and viral interactions in the microbiome
AU - Rowan-Nash, Aislinn D.
AU - Korry, Benjamin J.
AU - Mylonakis, Eleftherios
AU - Belenky, Peter
N1 - Funding Information:
This work was supported by the U.S. Department of Defense through the Peer Reviewed Medical Research Program under award number W81XWH-18-1-0198, by the National Science Foundation through the Graduate Research Fellowship Program under award number 1644760, and by the National Institutes of Health under institutional development awards P20GM109035 and P20GM121344 from the National Institute of General Medical Sciences, which fund the COBRE Center for Computational Biology of Human Disease and the Center for Antimicrobial Resistance and Therapeutic Discovery, respectively. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the Department of Defense, the National Science Foundation, or the National Institutes of Health. The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. We declare no conflicts of interest.
Publisher Copyright:
Copyright © 2019 American Society for Microbiology. All Rights Reserved.
PY - 2019/3
Y1 - 2019/3
N2 - The importance of the microbiome to human health is increasingly recognized and has become a major focus of recent research. However, much of the work has focused on a few aspects, particularly the bacterial component of the microbiome, most frequently in the gastrointestinal tract. Yet humans and other animals can be colonized by a wide array of organisms spanning all domains of life, including bacteria and archaea, unicellular eukaryotes such as fungi, multicellular eukaryotes such as helminths, and viruses. As they share the same host niches, they can compete with, synergize with, and antagonize each other, with potential impacts on their host. Here, we discuss these major groups making up the human microbiome, with a focus on how they interact with each other and their multicellular host.
AB - The importance of the microbiome to human health is increasingly recognized and has become a major focus of recent research. However, much of the work has focused on a few aspects, particularly the bacterial component of the microbiome, most frequently in the gastrointestinal tract. Yet humans and other animals can be colonized by a wide array of organisms spanning all domains of life, including bacteria and archaea, unicellular eukaryotes such as fungi, multicellular eukaryotes such as helminths, and viruses. As they share the same host niches, they can compete with, synergize with, and antagonize each other, with potential impacts on their host. Here, we discuss these major groups making up the human microbiome, with a focus on how they interact with each other and their multicellular host.
KW - Archaea
KW - Bacteria
KW - Bacteriophage
KW - Cross-domain
KW - Fungi
KW - Helminths
KW - Microbiome
KW - Protozoa
KW - Virus
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U2 - 10.1128/MMBR.00044-18
DO - 10.1128/MMBR.00044-18
M3 - Review article
C2 - 30626617
AN - SCOPUS:85059799072
VL - 83
JO - Microbiology and Molecular Biology Reviews
JF - Microbiology and Molecular Biology Reviews
SN - 1092-2172
IS - 1
M1 - e00044
ER -