Cross-correlated relaxation between H1′ chemical shift anisotropy and H1′ - H2′ dipolar relaxation mechanisms in ribonucleosides: Application to the characterization of their anomeric configuration

Kumar Pichumani, Tilak Chandra, Xiang Zou, Kenneth L. Brown

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Cross-correlated nuclear spin relaxation between 1H chemical shift anisotropy (CSA) and 1H- 1H dipolar relaxation mechanisms in ribonucleosides in solution phase are observed and used to identify their anomeric configuration. Only α-ribonucleosides showed the presence of cross-correlated spin relaxation through differential spin-lattice relaxation (T1) of the H1′ doublet. Dependence of the magnitude and the orientation of the H1′ CSA tensor values on the glycosidic torsion angle and the fast time-scale internal motions present in the ribose moiety play a significant role in the characterization of the anomeric configuration of the nucleosides via cross-correlated relaxation.

Original languageEnglish (US)
Pages (from-to)5-8
Number of pages4
JournalJournal of Physical Chemistry B
Volume110
Issue number1
DOIs
StatePublished - Jan 12 2006

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films
  • Materials Chemistry

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