Cross-correlated relaxation between H1′ chemical shift anisotropy and H1′ - H2′ dipolar relaxation mechanisms in ribonucleosides: Application to the characterization of their anomeric configuration

Kumar Pichumani; Tilak Chandra; Xiang Zou; Kenneth L. Brown

doi:10.1021/jp055774m

Cross-correlated relaxation between H¹′ chemical shift anisotropy and H¹′ - H²′ dipolar relaxation mechanisms in ribonucleosides: Application to the characterization of their anomeric configuration

Kumar Pichumani, Tilak Chandra, Xiang Zou, Kenneth L. Brown

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Cross-correlated nuclear spin relaxation between ¹H chemical shift anisotropy (CSA) and ¹H- ¹H dipolar relaxation mechanisms in ribonucleosides in solution phase are observed and used to identify their anomeric configuration. Only α-ribonucleosides showed the presence of cross-correlated spin relaxation through differential spin-lattice relaxation (T₁) of the H¹′ doublet. Dependence of the magnitude and the orientation of the H¹′ CSA tensor values on the glycosidic torsion angle and the fast time-scale internal motions present in the ribose moiety play a significant role in the characterization of the anomeric configuration of the nucleosides via cross-correlated relaxation.

Original language	English (US)
Pages (from-to)	5-8
Number of pages	4
Journal	Journal of Physical Chemistry B
Volume	110
Issue number	1
DOIs	https://doi.org/10.1021/jp055774m
State	Published - Jan 12 2006

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Surfaces, Coatings and Films
Materials Chemistry

Access to Document

10.1021/jp055774m

Cite this

Research output: Contribution to journal › Article › peer-review

@article{f87ae65b22bf4640972ffdfb68301020,

title = "Cross-correlated relaxation between H1′ chemical shift anisotropy and H1′ - H2′ dipolar relaxation mechanisms in ribonucleosides: Application to the characterization of their anomeric configuration",

abstract = "Cross-correlated nuclear spin relaxation between 1H chemical shift anisotropy (CSA) and 1H- 1H dipolar relaxation mechanisms in ribonucleosides in solution phase are observed and used to identify their anomeric configuration. Only α-ribonucleosides showed the presence of cross-correlated spin relaxation through differential spin-lattice relaxation (T1) of the H1′ doublet. Dependence of the magnitude and the orientation of the H1′ CSA tensor values on the glycosidic torsion angle and the fast time-scale internal motions present in the ribose moiety play a significant role in the characterization of the anomeric configuration of the nucleosides via cross-correlated relaxation.",

author = "Kumar Pichumani and Tilak Chandra and Xiang Zou and Brown, {Kenneth L.}",

year = "2006",

month = jan,

day = "12",

doi = "10.1021/jp055774m",

language = "English (US)",

volume = "110",

pages = "5--8",

journal = "Journal of Physical Chemistry B",

issn = "1520-6106",

publisher = "American Chemical Society",

number = "1",

}

TY - JOUR

T1 - Cross-correlated relaxation between H1′ chemical shift anisotropy and H1′ - H2′ dipolar relaxation mechanisms in ribonucleosides

T2 - Application to the characterization of their anomeric configuration

AU - Pichumani, Kumar

AU - Chandra, Tilak

AU - Zou, Xiang

AU - Brown, Kenneth L.

PY - 2006/1/12

Y1 - 2006/1/12

N2 - Cross-correlated nuclear spin relaxation between 1H chemical shift anisotropy (CSA) and 1H- 1H dipolar relaxation mechanisms in ribonucleosides in solution phase are observed and used to identify their anomeric configuration. Only α-ribonucleosides showed the presence of cross-correlated spin relaxation through differential spin-lattice relaxation (T1) of the H1′ doublet. Dependence of the magnitude and the orientation of the H1′ CSA tensor values on the glycosidic torsion angle and the fast time-scale internal motions present in the ribose moiety play a significant role in the characterization of the anomeric configuration of the nucleosides via cross-correlated relaxation.

AB - Cross-correlated nuclear spin relaxation between 1H chemical shift anisotropy (CSA) and 1H- 1H dipolar relaxation mechanisms in ribonucleosides in solution phase are observed and used to identify their anomeric configuration. Only α-ribonucleosides showed the presence of cross-correlated spin relaxation through differential spin-lattice relaxation (T1) of the H1′ doublet. Dependence of the magnitude and the orientation of the H1′ CSA tensor values on the glycosidic torsion angle and the fast time-scale internal motions present in the ribose moiety play a significant role in the characterization of the anomeric configuration of the nucleosides via cross-correlated relaxation.

UR - http://www.scopus.com/inward/record.url?scp=31144444998&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=31144444998&partnerID=8YFLogxK

U2 - 10.1021/jp055774m

DO - 10.1021/jp055774m

M3 - Article

C2 - 16471486

AN - SCOPUS:31144444998

SN - 1520-6106

VL - 110

SP - 5

EP - 8

JO - Journal of Physical Chemistry B

JF - Journal of Physical Chemistry B

IS - 1

ER -

Cross-correlated relaxation between H¹′ chemical shift anisotropy and H¹′ - H²′ dipolar relaxation mechanisms in ribonucleosides: Application to the characterization of their anomeric configuration

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this