@article{dd379c77cbf44306ae22d1f0bbd500f3,
title = "Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer",
abstract = "Obesity is a major risk factor for adverse outcomes in breast cancer. Maguire, Ackerman et al. reveal Gatm and Acsbg1 as molecular regulators of obesity-driven breast cancer progression. They further show that in obesity creatine is a key metabolite in the crosstalk between adipocytes and breast tumors.",
keywords = "Acsbg1, Gatm, breast cancer, creatine, hypoxia, obesity",
author = "Maguire, {Olivia A.} and Ackerman, {Sarah E.} and Szwed, {Sarah K.} and Maganti, {Aarthi V.} and Fran{\c c}ois Marchildon and Xiaojing Huang and Kramer, {Daniel J.} and Adriana Rosas-Villegas and Gelfer, {Rebecca G.} and Turner, {Lauren E.} and Victor Ceballos and Asal Hejazi and Bozena Samborska and Rahbani, {Janane F.} and Dykstra, {Christien B.} and Annis, {Matthew G.} and Luo, {Ji Dung} and Carroll, {Thomas S.} and Jiang, {Caroline S.} and Dannenberg, {Andrew J.} and Siegel, {Peter M.} and Tersey, {Sarah A.} and Mirmira, {Raghavendra G.} and Lawrence Kazak and Paul Cohen",
note = "Funding Information: We thank J.M. Friedman, B. Hirschhorn, B.M. Spiegelman, and S. Tavazoie for feedback and discussions. O.A.M., S.K.S., D.J.K., and R.G.G. have been supported by a Medical Scientist Training Program grant from the National Institute of General Medical Sciences of the National Institutes of Health under award number T32GM007739 to the Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program; L.E.T. and V.C. were supported by the Tri-Institutional MD-PhD Gateways to the Laboratory Program; R.G.M. was supported by R01 DK060581 and R01 DK124096 ; P.M.S. was supported by a Terry Fox New Frontiers Program Grant ( 251427-251690 ); L.K. was supported by a Canadian Institutes of Health Research Grant ( PJT-159529 ) and by the Canadian Foundation for Innovation John R. Evans Leaders Fund ( 37919 ); and P.C. was supported by Susan G. Komen ( CCR16377602 ). The contents in this manuscript are those of the authors and do not necessarily reflect the view of the U.S. President{\textquoteright}s Emergency Plan for AIDS Relief, the U.S. Agency for International Development, or the U.S. Government. Funding Information: We thank J.M. Friedman, B. Hirschhorn, B.M. Spiegelman, and S. Tavazoie for feedback and discussions. O.A.M. S.K.S. D.J.K. and R.G.G. have been supported by a Medical Scientist Training Program grant from the National Institute of General Medical Sciences of the National Institutes of Health under award number T32GM007739 to the Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program; L.E.T. and V.C. were supported by the Tri-Institutional MD-PhD Gateways to the Laboratory Program; R.G.M. was supported by R01 DK060581 and R01 DK124096; P.M.S. was supported by a Terry Fox New Frontiers Program Grant (251427-251690); L.K. was supported by a Canadian Institutes of Health Research Grant (PJT-159529) and by the Canadian Foundation for Innovation John R. Evans Leaders Fund (37919); and P.C. was supported by Susan G. Komen (CCR16377602). The contents in this manuscript are those of the authors and do not necessarily reflect the view of the U.S. President's Emergency Plan for AIDS Relief, the U.S. Agency for International Development, or the U.S. Government. P.C. conceived of the project and supervised the research. P.C. O.A.M. and S.E.A. designed the experiments. O.A.M. S.E.A. S.K.S. A.V.M. F.M. X.H. D.J.K. A.R.-V. R.G.G. L.E.T. V.C. A.H. B.S. J.F.R. C.B.D. and M.G.A. performed, analyzed, and/or assisted with experiments. O.A.M. S.E.A. J.-D.L. T.S.C. and C.S.J. analyzed the data. O.A.M. S.E.A. and P.C. wrote the manuscript with contributions from all authors. A.J.D. P.M.S. S.A.T. R.G.M. and L.K. provided reagents and intellectual input. The authors declare no competing interests. One or more of the authors of this paper self-identifies as an underrepresented ethnic minority in science. One or more of the authors of this paper self-identifies as a member of the LGBTQ+ community. One of more of the authors of this paper received support from a program designed to increase minority representation in science. Publisher Copyright: {\textcopyright} 2021 Elsevier Inc. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = mar,
day = "2",
doi = "10.1016/j.cmet.2021.01.018",
language = "English (US)",
volume = "33",
pages = "499--512.e6",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "3",
}