Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer

Olivia A. Maguire, Sarah E. Ackerman, Sarah K. Szwed, Aarthi V. Maganti, François Marchildon, Xiaojing Huang, Daniel J. Kramer, Adriana Rosas-Villegas, Rebecca G. Gelfer, Lauren E. Turner, Victor Ceballos, Asal Hejazi, Bozena Samborska, Janane F. Rahbani, Christien B. Dykstra, Matthew G. Annis, Ji Dung Luo, Thomas S. Carroll, Caroline S. Jiang, Andrew J. DannenbergPeter M. Siegel, Sarah A. Tersey, Raghavendra G. Mirmira, Lawrence Kazak, Paul Cohen

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Obesity is a major risk factor for adverse outcomes in breast cancer. Maguire, Ackerman et al. reveal Gatm and Acsbg1 as molecular regulators of obesity-driven breast cancer progression. They further show that in obesity creatine is a key metabolite in the crosstalk between adipocytes and breast tumors.

Original languageEnglish (US)
Pages (from-to)499-512.e6
JournalCell Metabolism
Volume33
Issue number3
DOIs
StatePublished - Mar 2 2021

Keywords

  • Acsbg1
  • Gatm
  • breast cancer
  • creatine
  • hypoxia
  • obesity

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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