TY - JOUR
T1 - COX-2 inhibition in upper aerodigestive tract tumors
AU - Altorki, Nasser K.
AU - Subbaramaiah, Kotha
AU - Dannenberg, Andrew J.
N1 - Funding Information:
Supported in part by Pharmacia Corporation.
PY - 2004/4
Y1 - 2004/4
N2 - Evidence continues to accumulate that cyclooxygenase-2 (COX-2), an inducible COX isoform, represents a potential pharmacological target for the prevention and treatment of cancer, including tumors affecting the upper aerodigestive tract. Studies in experimental models of these malignancies show that selective COX-2 inhibitors reduce tumor formation and growth. Clinical studies have been initiated to determine the chemopreventive effects of selective COX-2 inhibitors in patients with oral leukoplakia and Barrett's esophagus, and other studies are assessing the feasibility of incorporating these agents into existing treatment modalities for patients with locally advanced or metastatic cancer.
AB - Evidence continues to accumulate that cyclooxygenase-2 (COX-2), an inducible COX isoform, represents a potential pharmacological target for the prevention and treatment of cancer, including tumors affecting the upper aerodigestive tract. Studies in experimental models of these malignancies show that selective COX-2 inhibitors reduce tumor formation and growth. Clinical studies have been initiated to determine the chemopreventive effects of selective COX-2 inhibitors in patients with oral leukoplakia and Barrett's esophagus, and other studies are assessing the feasibility of incorporating these agents into existing treatment modalities for patients with locally advanced or metastatic cancer.
UR - http://www.scopus.com/inward/record.url?scp=3042759696&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3042759696&partnerID=8YFLogxK
U2 - 10.1053/j.seminoncol.2004.03.043
DO - 10.1053/j.seminoncol.2004.03.043
M3 - Review article
C2 - 15252927
AN - SCOPUS:3042759696
SN - 0093-7754
VL - 31
SP - 30
EP - 35
JO - Seminars in Oncology
JF - Seminars in Oncology
IS - SUPPL. 7
ER -