Coupling tumor growth and bio distribution models

Raffaella Santagiuliana, Miljan Milosevic, Bogdan Milicevic, Giuseppe Sciumè, Vladimir Simic, Arturas Ziemys, Milos Kojic, Bernhard A. Schrefler

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

We couple a tumor growth model embedded in a microenvironment, with a bio distribution model able to simulate a whole organ. The growth model yields the evolution of tumor cell population, of the differential pressure between cell populations, of porosity of ECM, of consumption of nutrients due to tumor growth, of angiogenesis, and related growth factors as function of the locally available nutrient. The bio distribution model on the other hand operates on a frozen geometry but yields a much refined distribution of nutrient and other molecules. The combination of both models will enable simulating the growth of a tumor in a whole organ, including a realistic distribution of therapeutic agents and allow hence to evaluate the efficacy of these agents.

Original languageEnglish (US)
Article number33
JournalBiomedical Microdevices
Volume21
Issue number2
DOIs
StatePublished - Jun 1 2019

Keywords

  • Angiogenesis
  • Biodistribution
  • Code coupling
  • Modeling
  • Multiphase
  • Smearded finite element

ASJC Scopus subject areas

  • Biomedical Engineering
  • Molecular Biology

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