Coupling AAA protein function to regulated gene expression

Nicolas Joly, Nan Zhang, Martin Buck, Xiaodong Zhang

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations

Abstract

AAA proteins (ATPases Associated with various cellular Activities) are involved in almost all essential cellular processes ranging from DNA replication, transcription regulation to protein degradation. One class of AAA proteins has evolved to adapt to the specific task of coupling ATPase activity to activating transcription. These upstream promoter DNA bound AAA activator proteins contact their target substrate, the σ 54-RNA polymerase holoenzyme, through DNA looping, reminiscent of the eukaryotic enhance binding proteins. These specialised macromolecular machines remodel their substrates through ATP hydrolysis that ultimately leads to transcriptional activation. We will discuss how AAA proteins are specialised for this specific task. This article is part of a Special Issue entitled: AAA ATPases: structure and function.

Original languageEnglish (US)
Pages (from-to)108-116
Number of pages9
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Volume1823
Issue number1
DOIs
StatePublished - Jan 2012

Keywords

  • AAA ATPase
  • Enhancer binding protein
  • RNA polymerase
  • Sigma54
  • Structure-function relationship
  • Transcriptional activator

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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