TY - JOUR
T1 - Coupling AAA protein function to regulated gene expression
AU - Joly, Nicolas
AU - Zhang, Nan
AU - Buck, Martin
AU - Zhang, Xiaodong
N1 - Funding Information:
Work in XZ and MB's groups is funded by the BBSRC , the Wellcome Trust and the Leverhulm Trust . NJ is currently supported by the Centre National de la Recherche Scientifique (CNRS). We thank members of XZ and MB's groups for their stimulating discussions.
PY - 2012/1
Y1 - 2012/1
N2 - AAA proteins (ATPases Associated with various cellular Activities) are involved in almost all essential cellular processes ranging from DNA replication, transcription regulation to protein degradation. One class of AAA proteins has evolved to adapt to the specific task of coupling ATPase activity to activating transcription. These upstream promoter DNA bound AAA activator proteins contact their target substrate, the σ 54-RNA polymerase holoenzyme, through DNA looping, reminiscent of the eukaryotic enhance binding proteins. These specialised macromolecular machines remodel their substrates through ATP hydrolysis that ultimately leads to transcriptional activation. We will discuss how AAA proteins are specialised for this specific task. This article is part of a Special Issue entitled: AAA ATPases: structure and function.
AB - AAA proteins (ATPases Associated with various cellular Activities) are involved in almost all essential cellular processes ranging from DNA replication, transcription regulation to protein degradation. One class of AAA proteins has evolved to adapt to the specific task of coupling ATPase activity to activating transcription. These upstream promoter DNA bound AAA activator proteins contact their target substrate, the σ 54-RNA polymerase holoenzyme, through DNA looping, reminiscent of the eukaryotic enhance binding proteins. These specialised macromolecular machines remodel their substrates through ATP hydrolysis that ultimately leads to transcriptional activation. We will discuss how AAA proteins are specialised for this specific task. This article is part of a Special Issue entitled: AAA ATPases: structure and function.
KW - AAA ATPase
KW - Enhancer binding protein
KW - RNA polymerase
KW - Sigma54
KW - Structure-function relationship
KW - Transcriptional activator
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U2 - 10.1016/j.bbamcr.2011.08.012
DO - 10.1016/j.bbamcr.2011.08.012
M3 - Review article
C2 - 21906631
AN - SCOPUS:84855207431
VL - 1823
SP - 108
EP - 116
JO - Biochimica et Biophysica Acta - Molecular Cell Research
JF - Biochimica et Biophysica Acta - Molecular Cell Research
SN - 0167-4889
IS - 1
ER -