Cost-effectiveness of revascularization for limb preservation in patients with marginal functional status

Neal R. Barshes, Panos Kougias, C. Keith Ozaki, George Pisimisis, Carlos F. Bechara, Helene K. Henson, Michael Belkin

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Background Revascularization and limb salvage attempts are often offered to patients with foot wounds and chronic limb ischemia who are thought to be good-risk candidates, but some skepticism remains about the utility of these efforts for elderly patients with marginal functional status. We sought to determine whether limb preservation efforts in this population could be justified from a patient-centered, cost-effectiveness perspective. Methods A probabilistic Markov model was used to simulate the clinical outcomes, health utilities, and costs over a 10-year period with various management strategies. Clinical parameter estimates were obtained from previous clinical trials and large observational series. Cost estimates were obtained from cost literature and also a single-center study that reviewed total costs accumulated (including secondary amputations, wound care, outpatient nursing care, and nursing home costs). Cost (in 2011 U.S. dollars) per year of ambulation (with limb preservation or with a prosthesis after amputation) was the primary measure of cost-effectiveness. Results The total 10-year costs of revascularization - either endovascular or surgical - were lower than the costs of either local wound care alone or primary amputation. Revascularization strategies also produced more health benefits as measured in terms of years of ambulatory ability, years of limb salvage, or quality-adjusted life-years. In none of the scenarios modeled in deterministic sensitivity analyses did primary amputation prove to be cost-effective. Conclusions Revascularization and limb preservation attempts appear less costly and provide more health benefits than wound care alone or primary amputation, even among patients with marginal functional status at baseline.

Original languageEnglish (US)
Pages (from-to)10-17
Number of pages8
JournalAnnals of Vascular Surgery
Issue number1
StatePublished - Jan 2014

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine


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