Corticosteroids for the treatment of non-arteritic anterior ischemic optic neuropathy

Nagham Al-Zubidi; Margaret M. McGlynn; Sushma Yalamanchili; Andrew G. Lee

doi:10.1586/17469899.2013.852956

Corticosteroids for the treatment of non-arteritic anterior ischemic optic neuropathy

Nagham Al-Zubidi, Margaret M. McGlynn, Sushma Yalamanchili, Andrew G. Lee

Research output: Contribution to journal › Review article › peer-review

Abstract

Non-arteritic anterior ischemic optic neuropathy (NAION) is the most common cause of an acute unilateral optic neuropathy in patients older than 50 years of age. Its consequences range from temporarily disabling to permanently blinding. Unfortunately, the pathophysiology of NAION is incompletely understood and no proven effective treatment for NAION currently exists. Numerous theories have been proposed regarding the pathophysiology of NAION including hypoperfusion of the optic nerve, nocturnal hypotension, and in rare cases thrombotic or embolic etiologies. Notably, newer evidence has implicated possible inflammatory processes in NAION leading to potential, theoretical benefit from corticosteroid treatment. This review will spotlight the pros and cons of corticosteroid treatment in NAION.

Original language	English (US)
Pages (from-to)	577-580
Number of pages	4
Journal	Expert Review of Ophthalmology
Volume	8
Issue number	6
DOIs	https://doi.org/10.1586/17469899.2013.852956
State	Published - 2013

Keywords

Corticosteroids
Non-arteritic anterior ischemic optic neuropathy

ASJC Scopus subject areas

Ophthalmology
Biomedical Engineering
Optometry

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10.1586/17469899.2013.852956

Cite this

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title = "Corticosteroids for the treatment of non-arteritic anterior ischemic optic neuropathy",

abstract = "Non-arteritic anterior ischemic optic neuropathy (NAION) is the most common cause of an acute unilateral optic neuropathy in patients older than 50 years of age. Its consequences range from temporarily disabling to permanently blinding. Unfortunately, the pathophysiology of NAION is incompletely understood and no proven effective treatment for NAION currently exists. Numerous theories have been proposed regarding the pathophysiology of NAION including hypoperfusion of the optic nerve, nocturnal hypotension, and in rare cases thrombotic or embolic etiologies. Notably, newer evidence has implicated possible inflammatory processes in NAION leading to potential, theoretical benefit from corticosteroid treatment. This review will spotlight the pros and cons of corticosteroid treatment in NAION.",

keywords = "Corticosteroids, Non-arteritic anterior ischemic optic neuropathy",

author = "Nagham Al-Zubidi and McGlynn, \{Margaret M.\} and Sushma Yalamanchili and Lee, \{Andrew G.\}",

note = "Funding Information: The authors were supported by in part by an unrestricted grant from Research to Prevent Blindness. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.",

year = "2013",

doi = "10.1586/17469899.2013.852956",

language = "English (US)",

volume = "8",

pages = "577--580",

journal = "Expert Review of Ophthalmology",

issn = "1746-9899",

publisher = "Taylor and Francis Ltd.",

number = "6",

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TY - JOUR

T1 - Corticosteroids for the treatment of non-arteritic anterior ischemic optic neuropathy

AU - Al-Zubidi, Nagham

AU - McGlynn, Margaret M.

AU - Yalamanchili, Sushma

AU - Lee, Andrew G.

N1 - Funding Information: The authors were supported by in part by an unrestricted grant from Research to Prevent Blindness. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

PY - 2013

Y1 - 2013

N2 - Non-arteritic anterior ischemic optic neuropathy (NAION) is the most common cause of an acute unilateral optic neuropathy in patients older than 50 years of age. Its consequences range from temporarily disabling to permanently blinding. Unfortunately, the pathophysiology of NAION is incompletely understood and no proven effective treatment for NAION currently exists. Numerous theories have been proposed regarding the pathophysiology of NAION including hypoperfusion of the optic nerve, nocturnal hypotension, and in rare cases thrombotic or embolic etiologies. Notably, newer evidence has implicated possible inflammatory processes in NAION leading to potential, theoretical benefit from corticosteroid treatment. This review will spotlight the pros and cons of corticosteroid treatment in NAION.

AB - Non-arteritic anterior ischemic optic neuropathy (NAION) is the most common cause of an acute unilateral optic neuropathy in patients older than 50 years of age. Its consequences range from temporarily disabling to permanently blinding. Unfortunately, the pathophysiology of NAION is incompletely understood and no proven effective treatment for NAION currently exists. Numerous theories have been proposed regarding the pathophysiology of NAION including hypoperfusion of the optic nerve, nocturnal hypotension, and in rare cases thrombotic or embolic etiologies. Notably, newer evidence has implicated possible inflammatory processes in NAION leading to potential, theoretical benefit from corticosteroid treatment. This review will spotlight the pros and cons of corticosteroid treatment in NAION.

KW - Corticosteroids

KW - Non-arteritic anterior ischemic optic neuropathy

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DO - 10.1586/17469899.2013.852956

M3 - Review article

AN - SCOPUS:84888102665

SN - 1746-9899

VL - 8

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JO - Expert Review of Ophthalmology

JF - Expert Review of Ophthalmology

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ER -

Corticosteroids for the treatment of non-arteritic anterior ischemic optic neuropathy

Abstract

Keywords

ASJC Scopus subject areas

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