Cortexin diffusion in human eye sclera

E. A. Genina, A. N. Bashkatov, V. V. Tuchin, M. G. Ghosn, K. V. Larin, T. G. Kamenskikh

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Investigation of the diffusion of cytamines, a typical representative of which is cortexin, is important for evaluating the drug dose, necessary to provide sufflcient concentration of the preparation in the inner tissues of the eye. In the present paper, the cortexin diffusion rate in the eye sclera is measured using the methods of optical coherence tomography (OCT) and reflectance spectroscopy. The technique for determining the diffusion coefflcient is based on the registration of temporal dependence of the eye sclera scattering parameters caused by partial replacement of interstitial fluid with the aqueous cortexin solution, which reduces the level of the OCT signal and decreases the reflectance of the sclera. The values of the cortexin diffusion coefflcient obtained using two independent optical methods are in good agreement.

Original languageEnglish (US)
Pages (from-to)407-413
Number of pages7
JournalQuantum Electronics
Volume41
Issue number5
DOIs
StatePublished - 2011

Keywords

  • Diffusion coefflcient
  • Drug delivery
  • Optical coherence tomography
  • Reflectance spectros-copy

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Statistical and Nonlinear Physics
  • Atomic and Molecular Physics, and Optics
  • Electrical and Electronic Engineering

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