Correlation of the outcome of renal transplantation with T cell flow cytometric immunofluorescence crossmatch results

J. R. Thistlethwaite, M. R. Buckingham, A. Osama Gaber

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The influence of crossmatch test sensitivity on the outcome of renal transplantation is not clearly established. However, acute irreversible rejection is the most frequent cause of renal allograft failure; undetected recipient preimmunization may be a contributing factor. Thus, there has been a continued effort to develop more sensitive crossmatch techniques. Recently, Garavoy et al have described a technique which detects the binding of antibodies in recipient sera to donor lymphocytes using an immunofluorescent reagent detectable with the fluorescence activated cell sorter. Preliminary results from several labs including our own have suggested that immunofluorescent flow cytometric crossmatches are more sensitive than standard serological techniques which depend on complement dependent cytotoxicity and may be useful in predicting the outcome of renal transplantation. We have used the T cell flow cytometric (FC) immunofluorescence crossmatch to identify what we think is a high risk population of renal transplant recipients.

Original languageEnglish (US)
Pages (from-to)440-442
Number of pages3
JournalTransplantation Proceedings
Volume18
Issue number3
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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