Correlation of serum IgG,IgM, and anti-native-DNA antibodies with renal and clinical indexes of activity in systemic lupus erythematosus

M. D. Feldman, David P. Huston, J. Karsh, J. E. Balow, E. Klima, A. D. Steinberg

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Sera from 59 systemic lupus erythematosus (SLE) patients were studied for IgG and IgM and titers of antibodies to n-DNA detected by Farr assay and by a class specific (IgG or IgM) enzyme labeled immunoabsorbent assay (ELISA). Correlations with clinical SLE activity and renal histology were made using Spearman rank order analysis. For many patients each of the serologic parameters correlated significantly with SLE clinical activity, but only the IgG ELISA and the Farr assay for anti-n-DNA antibodies correlated significantly with active renal histology. By obviating the need for radionucleotides, the ELISA may be a preferable technique for measuring anti-n-DNA antibodies in many laboratories.

Original languageEnglish (US)
Pages (from-to)52-58
Number of pages7
JournalJournal of Rheumatology
Volume9
Issue number1
StatePublished - Dec 1 1982

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Correlation of serum IgG,IgM, and anti-native-DNA antibodies with renal and clinical indexes of activity in systemic lupus erythematosus'. Together they form a unique fingerprint.

Cite this